早发性精神分裂症患者头颅CT扫描参数变化与认知功能异常的关系

Relationship between the changes of head CT scan parameters and cognitive function abnormalities in patients with early-onset schizophrenia

目的探讨早发精神分裂症患者头颅CT扫描参数的变化与患者认知功能异常的关系。方法选取我院80例首发精神分裂症患者作为病例组,另选取年龄及性别等因素匹配的80例体检志愿者作为对照组,患者的诊断时间为2017年2月~2021年3月,两组研究对象均愿意接受头颅CT扫描,对比两组研究对象CT检查发现的脑结构异常、脑叶参数、认知功能评分,采用相关性分析法探讨脑结构异常、脑叶参数与患者认知功能的相关性。结果病例组的皮质型、髓质型、皮髓质混合型、脑萎缩总体发生率均显著高于对照组(P<0.05);病例组的额叶平均CT值低于对照组(P<0.05);两组在颞叶、顶叶、枕叶的CT值差异无统计学意义(P>0.05);病例组的信息处理速度、注意/警觉性、工作记忆、社会认知、总体认知得分上低于对照组(P<0.05);两组词语记忆、视觉学习、推理与问题解决的得分差异无统计学意义(P>0.05);病例组脑萎缩患者的信息处理速度、注意/警觉性、工作记忆、社会认知、总体认知得分上低于未发生脑萎缩患者(P<0.05);两组词语记忆、视觉学习、推理与问题解决的得分差异无统计学意义(P>0.05);病例组额叶CT值与信息处理速度、工作记忆、社会认知、总体认知得分呈正相关(P<0.05)。结论早发精神分裂症患者头颅CT扫描可发现患者脑萎缩的检出率明显增加,额叶CT值降低,这些变化与患者认知功能受损存在密切关系。

Objective To explore the relationship between the changes of head CT scan parameters and cognitive function abnormalities in patients with early-onset schizophrenia.Methods We selected 80 first-onset schizophrenia patients(case group),80 physical examination volunteers(control group)with basically matched factors such as age and gender.The diagnosis time of the patients was February 2017 to March 2021.The patients acceptted head CT scans.We compared the brain structure abnormalities,brain lobe parameters,and cognitive function scores found in the CT examination of the two groups.The correlation analysis was used to explore the correlation between brain structure abnormalities,brain lobe parameters and patients'cognitive functions.Results The overall incidence of cortical,medullary,mixed cortical and medullary,and brain atrophy in the case group were significantly higher than those in the control group(P<0.05).The average CT value of the frontal lobe of the case group was lower than the control group(P<0.05).Two groups had no significant difference in CT values in the temporal lobe,parietal lobe,and occipital lobe(P>0.05).The scores of attention/alertness,working memory,social cognition,and overall cognition were lower than those of the control group(P<0.05).Two groups had scores on word memory,visual learning,reasoning and problem solving(P>0.05).The information processing speed,attention/alertness,working memory,social cognition,and overall cognition scores of patients with brain atrophy in the case group were lower than those without brain atrophy(P<0.05).The two groups had no significant differences in the scores of word memory,visual learning,reasoning and problem solving(P>0.05).The frontal lobe CT value of the case group and the speed of information processing,working memory,social Cognition and overall cognition scores were positively correlated(P<0.05).Conclusion CT scan of the brain of patients with early-onset schizophrenia can find that the detection rate of brain atrophy is significantly increased.CT value of the frontal lobe is decreased.These changes are closely related to the impaired cognitive function of the patient.