^(99m)Tc-3PRGD2 SPECT/CT显像用于肺部肿瘤分期及疗效评估的研究进展

Research progress of ^(99m)Tc-3PRGD2 SPECT/CT in staging and efficacy evaluation of lung tumors

近年来,肺癌发病率逐年上升,也是恶性肿瘤中致死率排名第1位的疾病,晚期患者生存率极低。血管生成和淋巴结转移是恶性肿瘤的两个非常重要的特征,通常认为整合素αvβ3的表达与这两个特征均有关。放射性核素标记的精氨酸-甘氨酸-天冬氨酸肽能与整合素特异的结合,进而可以反映肿瘤血管的变化。达到对肺癌原发灶、转移灶及疗效的早期监测,本文对近年来国内外^(99m)Tc-3PRGD2 SPECT/CT用于肺部肿瘤诊断的研究进展进行综述,主要从^(99m)Tc-3PRGD2显像剂、9mTc-3PRGD2在肺癌原发灶显像方面、^(99m)Tc-3PRGD2 SPECT显像对非小细胞肺癌淋巴结转移监测、^(99m)Tc-3PRGD2 SPECT成像在肺癌患者远处转移的诊断、^(99m)Tc-3PRGD2 SPECT成像在肺癌患者化疗、靶向药物疗效评估等几个方面展开论述。

In recent years,the incidence of lung cancer has been increasing year by year,and it is also the most fatal disease among malignant tumors.The survival rate of advanced patients is extremely low.Angiogenesis and lymph node metastasis are two very important characteristics of malignant tumors.It is generally believed that the expression of integrin αvβ3 is related to both of these characteristics.The radionuclide-labeled arginine-glycine-aspartic acid peptide can specifically bind to integrins,which can then reflect the changes in tumor blood vessels.To achieve the early monitoring of lung cancer primary tumors,metastases and efficacy,this article reviews the research progress of ^(99m)Tc-3PRGD2 SPECT/CT in lung tumor diagnosis at home and abroad in recent years.