慢性下腰痛的脑功能磁共振及动脉自旋标记灌注成像研究进展

Research advances of cerebral functional magnetic resonance imaging and arterial spin labeling perfusion imaging in chronic low back pain

慢性下腰痛在现代社会中是一种常见的症状,越来越多的证据表明,中枢神经系统在非特异性慢性下腰痛的发生、发展过程中起着关键的作用。功能磁共振能够显示慢性下腰痛患者脑内神经活动的细节、追踪大脑功能的变化。动脉自旋标记灌注成像通过标记动脉血中的水氢质子来获得脑血流量等灌注信息,从而评估疼痛相关脑灌注改变。本文旨在将功能磁共振和动脉自旋标记在慢性下腰痛中的相关基础和临床研究进行综述,主要包括fMRI在CLBP中的应用研究,rs-fMRI在CLBP中的应用,CLBP患者脑rs-fMRI的ReHo异常,CLBP患者脑rs-fMRI的ALFF异常,CLBP患者脑rs-fMRI的默认模式网络(DMN)异常,任务态fMRI在CLBP中的应用,ASL灌注成像在CLBP中的应用研究,探究功能磁共振和动脉自旋标记在慢性下腰痛中的应用价值和研究前景。

Chronic low back pain(CLBP)is a common symptom in modern society,more and more evidence shows that the central nervous system plays a crucial role in the occurrence and development of non-specific CLBP.Functional magnetic resonance imaging can reveal detailed neurological activity in the brain of patients with CLBP and track changes in cerebral function.Arterial spin-labeled perfusion imaging evaluates pain-related cerebral perfusion changes by labeling water hydrogen protons in arterial blood to obtain perfusion information such as cerebral blood flow.This article reviews the basic and clinical research of functional magnetic resonance imaging and Arterial spin-labeled perfusion imaging in CLBP,and discusses the application value and research prospect of functional magnetic resonance imaging and arterial spin-labeled in CLBP.