西洛他唑联合阿司匹林与氯吡格雷治疗PCI术后急性心肌梗死患者的效果

Effects of Cilostazol combined with Aspirin and Clopidogrel in treatment of patients with acute myocardial infarction after PCI

目的:观察西洛他唑联合阿司匹林与氯吡格雷治疗经皮冠状动脉介入术(PCI)术后急性心肌梗死患者的效果。方法:回顾性分析2017年8月至2019年8月该院收治的80例PCI术后急性心肌梗死患者的临床资料,根据治疗方案不同将其分为对照组与观察组各40例。对照组给予阿司匹林联合硫酸氯吡格雷治疗,观察组在对照组基础上加用西洛他唑治疗,比较两组治疗前后血小板聚集率、心脏不良事件发生率和不良反应发生率。结果:治疗后,观察组血小板聚集率和心脏不良事件发生率均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:西洛他唑联合氯吡格雷与阿司匹林治疗PCI术后急性心肌梗死患者可降低血小板聚集率和心脏不良事件发生率,其效果优于阿司匹林联合硫酸氯吡格雷治疗。

Objective:To analyze effects of Cilostazol combined with Aspirin and Clopidogrel in treatment of patients with acute myocardial infarction after percutaneous coronary intervention(PCI).Methods:The clinical data of 80 patients with acute myocardial infarction after PCI admitted to the hospital from August 2017 to August 2019 were retrospectively analyzed.According to the different treatment options,they were divided into control group and observation group,each with 40 cases.The control group was treated with Aspirin combined with Clopidogrel sulfate,while the observation group was treated with Cilostazol on the basis of those of the control group.The platelet aggregation rate,the incidence of cardiac adverse events and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After treatment,the platelet aggregation rate and the incidence of cardiac adverse events in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Cilostazol combined with Clopidogrel and Aspirin can reduce the platelet aggregation rate and the incidence of cardiac adverse events in the patients with acute myocardial infarction after PCI.Moreover,it is superior to Aspirin combined with Clopidogrel sulfate treatment.