肩袖损伤患者TNF-α、IL-1β及IL-10表达及与肩部疼痛的相关性

Expression of TNF-α,IL-1β and IL-10 in patients with rotator cuff injury and their correlation with shoulder pain

目的分析肩袖损伤患者肩峰下滑囊(SAB)组织中肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)及白细胞介素-10(IL-10)表达及与肩部疼痛的相关性。方法选取2018年1月至2021年1月本院收治的因肩袖损伤或创伤性肩关节前方不稳定进行手术治疗的166例患者,其中85例肩袖损伤患者作为肩袖损伤组,81例创伤性肩关节前方不稳定患者作为肩关节不稳组。比较两组视觉模拟(VAS)评分及TNF-α、IL-1β、IL-10水平变化情况,采用Pearson相关分析法,绘制散点图分析肩关节疼痛VAS评分与肩袖损伤患者TNF-α、IL-1β及IL-10的相关性。结果两组性别、年龄、病程及体重指数等一般资料比较差异无统计学意义(P>0.05)。肩袖损伤组VAS评分及TNF-α、IL-1β水平均显著高于肩关节不稳组,IL-10水平显著低于肩关节不稳组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,肩关节疼痛VAS评分与肩峰下滑囊组织中TNF-α、IL-1β水平均呈正相关(P<0.05),与IL-10水平呈显著负相关(P<0.05)。结论肩袖损伤患者SAB组织中TNF-α、IL-1β及IL-10水平均发生异常改变,可能是肩袖损伤后引起肩关节疼痛的发病机制之一。

Objective To analyze the expression of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β) and interleukin-10(IL-10) in the subacromial bursa(SAB) tissue of patients with rotator cuff injury and their correlation with shoulder pain.Method The clinical data of 166 patients who were treated with surgery for rotator cuff injury or anterior instability of traumatic shoulder joint from January 2018 to January2021 in our hospital were collected [85 cases with rotator cuff injury(rotator cuff injury group),81 cases with anterior instability of traumatic shoulder joint(shoulder joint instability group)].The visual analogy score(VAS) score and the changes of TNF-α,IL-1β,and IL-10 levels between the two groups were compared.The Pearson correlation analysis method was used,and the scatter diagram was drawn to analyze the correlation between the VAS score of shoulder joint pain and TNF-α,IL-1β and IL-10 in patients with rotator cuff injury.Result The VAS score and TNF-α and IL-1β levels in the rotator cuff injury group were significantly higher than those in the shoulder joint instability group,and the IL-10 level was significantly lower than that in the shoulder joint instability group,the difference was statistically significant(P<0.05).The results of Pearson correlation analysis showed that the VAS score of shoulder joint pain was positively correlated with the levels of TNF-α and IL-1β in the subacromial bursa(P<0.05),and was significantly negatively correlated with the level of IL-10(P<0.05).Conclusion Abnormal changes in TNF-α,IL-1β and IL-10 levels in SAB tissues of patients with rotator cuff injury may be one of the pathogenesis of shoulder joint pain after rotator cuff injury.