榄香烯腹腔灌注联合热疗治疗恶性腹腔积液疗效分析

目的观察榄香烯腹腔灌注联合热疗治疗恶性腹腔积液的安全性及有效性。方法将42例恶性肿瘤伴有恶性腹腔积液患者随机分为对照组(21例)与观察组(21例)。两组患者均行腹腔穿刺抽净腹水,对照组给予单独榄香烯腹腔内灌注榄香烯乳状注射液400〜600 mg。观察组在对照组基础上给予微波热疗。两组患者治疗2次/周,连续治疗2周。4周后,评价两组患者腹水程度,临床有效率及不良反应发生情况。结果治疗后观察组有效率80.95%;对照组有效率66.67%。两组比较差异有统计学意义(P<0.05)。两组患者生活质量评分结果显示,观察组稳定率90.47%与对照组稳定率71.43%比较差异有统计学意义(P<0.05)。两组患者在治疗期间均未出现严重不良反应,部分患者出现恶心、呕吐、发热、疼痛等不良反应,经对症治疗后均明显缓解。结论腹腔灌注榄香烯注射液联合微波热疗可明显控制恶性腹水,提高治疗有效率,改善患者生存质量,且毒副作用小,对恶性腹腔积液治疗有一定临床价值。

Objective To observe the safety and efiicacy of elemene intraperitoneal perfusion combined with hypertherniia in the treatment of malignant ascites.Methods 42 cases of malignant tumor with malignant ascites were randomly divided into control group(21 cases)and observation group(21 cases).Two groups were given intraperitoneal puncture to drain the ascites,the control group was given elemene alone intraperitoneal perfusion of elemene emulsion injection 400~600 mg.The observation group was given microwave hyperthermia on the basis of the control group.The patients in the two groups were treated twice a week for two weeks.After 4 weeks,the degree of ascites,clinical efficiency and adverse reactions were evaluated.Results After treatment,the efiective rate of the observation group was 80.95%and that of the control group was 66.67%.There was statistical difference between the two groups(P<0.05).The quality of life score of the two groups showed that the stability rate of the observation group was 90.47%and that of the control group was 71.43%(P<0.05).During the treatment,the patients in both groups had serious adverse reactions such as myelosuppression,liver and kidney function damage,and a few patients had adverse reactions such as nausea,vomiting,fever,pain and so on.After symptomatic treatment,the patients in both groups had achieved significant relief Conclusion Intraperitoneal infusion of elemene injection combined with microwave hyperthermia can significantly control malignant ascites,improve the efficiency of treatment,improve the quality of life of patients,and have little side efiects.It has a certain clinical value for the treatment of malignant ascites.