依达拉奉联合银杏达莫治疗急性脑梗死的临床效果及对患者神经功能的影响

Clinical effect of edaravone combined with ginkgo leaf extract and dipyridamole injection in the treatment of acute cerebral infarction and its effect on neurological function

目的观察依达拉奉联合银杏达莫治疗急性脑梗死的临床效果及对患者神经功能的影响。方法选取2018年1月-2019年6月新兴县人民医院收治的脑梗死确诊患者66例,依照随机数字表法分为观察组和对照组,各33例。在常规治疗基础上,对照组予银杏达莫注射液治疗,观察组在对照组基础上加用依达拉奉注射液治疗。比较2组患者临床治疗效果,治疗前与治疗后1 d、1周及1个月的神经功能缺损评分(NIHSS评分),不良反应及患者或家属治疗满意度。结果治疗14 d,观察组总有效率为90.91%,高于对照组的69.70%(χ^(2)=4.694,P=0.030);治疗后1 d、1周及1个月时2组患者NIHSS评分均较治疗前降低(P均<0.01),且观察组各时点评分均低于对照组(P<0.01);2组患者不良反应总发生率比较差异无统计学意义(P>0.05);观察组患者或家属治疗总满意度为96.97%,高于对照组的72.73%(χ^(2)=7.543,P=0.006)。结论依达拉奉联合银杏达莫治疗急性脑梗死的临床效果显著,可明显改善患者神经功能,且不良反应发生风险较低,患者或家属治疗满意度高,值得临床推广应用。

Objective To observe the clinical effect of edaravone combined with ginkgo leaf extract and dipyridamole injection in the treatment of acute cerebral infarction and its effect on neurological function.Methods Sixty-six patients with cerebral infarction diagnosed in Xinxing County Peopled Hospital from January 2018 to June 2019 were randomly divided into observation group and control group,with 33 cases in each group.On the basis of routine treatment,the control group was treated with Ginkgo Damo injection,and the observation group was treated with edaravone injection on the basis of the control group.The clinical treatment effect,neurological deficit score(NIHSS score)before and 1 day,1 week and 1 month after treatment,the occurrence of adverse reactions and the treatment satisfaction of patients or their families were compared between the two groups.Results After 14 days of treatment,the total effective rate in the observation group was 90.91%,higher than 69.70%in the control group(χ^(2)=4.694,P=0.030);At 1 day,1 week and 1 month after treatment,the NIHSS scores of the two groups were lower than those before treatment(P<0.01),and the scores of the observation group at each time point were lower than those of the control group(P<0.01);There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05);The total satisfaction of patients or their families in the observation group was 96.97%,higher than 72.73%in the control group(χ^(2)=7.543,P=0.006).Conclusion Edaravone combined with ginkgo leaf extract and dipyridamole injection has a significant clinical effect in the treatment of acute cerebral infarction,it can significantly improve the neurological function of patients,with low risk of adverse reactions and high treatment satisfaction of patients or their families,which is worthy of clinical application.