藁本内酯对缺血性脑卒中的神经保护作用研究进展

Advances in neuroprotective effects of ligustilide on ischemic stroke

缺血性脑卒中的发病率和死亡率逐年增加,严重影响患者的生活质量。藁本内酯是传统中药当归和川芎的主要活性成分,研究发现其可以通过多种效应如抗氧化应激、抗炎症反应、减轻脑水肿、保护血脑屏障、抗血小板聚集、改善认知障碍和抑制血管平滑肌细胞迁移,减轻缺血性脑卒中的神经损害,从而改善预后。

The morbidity and mortality of ischemic stroke are increasing year by year, which seriously affects the quality of life of patients. Ligustilide is the main active component of traditional Chinese medicine Angelica sinensis and Ligusticum chuanxiong Hort. It has been found that ligustilide can reduce the neurological damage of ischemic stroke through various effects such as anti-oxidative stress, anti-inflammation reaction, reduction of brain edema, protection of blood-brain barrier, inhibition of platelet aggregation, improvement of cognitive impairment and inhibition of vascular smooth muscle cell migration, so as to improve the prognosis.