糖耐量正常者75g口服葡萄糖耐量试验1 h血糖水平敏感性的影响因素分析

Analysis of influencing factors on sensitivity of blood glucose level in patients with normal glucose tolerance after 75g oral glucose tolerance test for 1 hour

目的分析糖耐量正常者75 g口服葡萄糖耐量(75 g OGTT)试验1 h血糖水平敏感性的影响因素。方法选择医院2019年1—12月1800例糖耐量者作为研究对象,根据75 g OGTT试验1 h血糖水平是否正常,分为对照组897例(75 gOGTT试验1 h血糖水平<8.6mmol/L)、病例组903例(75 g OGTT试验1 h血糖水平≥8.6 mmol/L)。通过单因素及多因素Logistic回归模型,分析影响糖耐量正常者75 gOGTT试验1 h血糖水平敏感性的相关因素。结果单因素分析显示,病例组与对照组的性别、运动时间比较,差异均无统计学意义(P>0.05);对照组的年龄、BMI、HbA1c、SBP、DBP、TC、TG、LDL-C、吸烟史、酗酒史低于病例组,HDL-C高于病例组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄≥60岁、BMI≥24、HbA1c≥6.1%、高血压、高血脂、吸烟史、酗酒史均是糖耐量正常者75 g OGTT试验1 h血糖水平的独立危险因素(P<0.05)。结论糖耐量正常者75 gOGTT试验1 h血糖水平的变化主要与年龄、BMI、HbA1c、血压、血脂等有关。

Objective To analyze the influencing factors of sensitivity of blood glucose level in patients with normal glucose tolerance after 75 g oral glucose tolerance test(75 g OGTT)for 1 hour.Methods To selected1,800 patients with normal glucose tolerance in our hospital from January to December 2019 as the study object.According to whether the 1 h blood glucose level of the 75 g OGTT test was normal,they were divided into a control group with 897 cases(75 g OGTT test 1 h blood sugar level<8.6 mmol/L)and a case group with 903 cases(75 g OGTT test 1 h blood glucose level≥8.6 mmol/L).Through univariate and multivariate Logistic regression models,the relevant factors affecting the sensitivity of the 1 h blood glucose level of the 75 g OGTT test in normal glucose tolerance patients were analyzed.Results:Univariate analysis showed that there was no statistically significant difference in gender and exercise time between the case group and the control group(P>0.05);the control group had lower age,BMI,HbAlc,SBP,DBP,TC,TG,LDL-C,smoking history and alcohol abuse history than the case group,the HDL-C was higher than the case group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the age≥60 years old,BMI≥24,HbAlc≥6.1%,hypertension,hyperlipidemia,history of smoking,and history of alcohol abuse were all independent risk factors for the 1-hour blood glucose level of 75 g OGTT test in patients with normal glucose tolerance(P<0.05).Conclusion The changes of 1 h blood glucose level in 75 g OGTT test of normal glucose tolerance patients were mainly related to age,BMI,HbAlc,blood pressure and blood lipids.