226例肺炎支原体肺炎患儿灌洗液中IL-8、sB7-H3水平表达对阿奇霉素治疗效果的影响

Influence of Expression of IL-8 and SB7-H3 in Lavage Fluid on Therapeutic Efficacy of Azithromycin in 226 Children with Mycoplasma Pneumoniae Pneumonia

目的:评价肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)患儿灌洗液中白介素-8(IL-8)、sB7-H3水平表达对阿奇霉素(AZM)治疗效果的影响。方法:选取医院2018年6月—2020年6月收治的均接受AZM治疗的MPP患儿226例病历资料,将其分为有效组(n=206)与无效组(n=20),统计其接受AZM治疗2周后的临床疗效以及治疗前灌洗液中IL-8、sB7-H3水平的表达,评价其治疗前灌洗液中IL-8、sB7-H3水平对MPP患儿AZM治疗的预测价值。结果:226例MPP患儿经AZM治疗2周后,治疗前2组患儿灌洗液中IL-8、sB7-H3水平测得值经比较其差异有统计学意义(P<0.05);并经Logistic回归分析法结果显示,治疗前MPP患儿灌洗液中IL-8、sB7-H3过表达与患儿经AZM治疗无效有关(OR>1,P<0.05);绘制ROC曲线分析结果显示,治疗前MPP患儿灌洗液中IL-8、sB7-H3水平变化对AZM治疗无效风险的AUC均>0.80,预测价值较为理想。结论:MPP患儿治疗前灌洗液中IL-8、sB7-H3水平表达与患儿经AZM治疗无效有关,可能是患儿对AZM治疗无效的风险因子,这对预测患儿AZM治疗无效风险的判别具有一定价值。

Objective: To evaluate the expression of IL-8 and sB7-H3 in lavage fluid on the therapeutic efficacy of azithromycin(AZM) in children with Mycoplasma pneumoniae pneumonia(MPP). Methods: Medical records of 226 MPP children treated with AZM in author’s hospital from June 2018 to June 2020 were selected and divided into effective group(n=206) and uneffective group(n=20). The clinical efficacy after receiving AZM treatment for 2 weeks and the expression levels of IL-8 and SB7-H3 in the lavage fluid before treatment were counted to evaluate the predictive value of the levels of IL-8 and SB7-H3 in the lavage fluid before treatment for AZM treatment in MPP children. Results: After treatment with AZM for 2 weeks, the levels of IL-8 and SB7-H3 in lavage fluid of 226 MPP children were significantly different between the two groups before treatment(P<0.05). Logistic regression analysis showed that the overexpression of IL-8 and SB7-H3 in lavage fluid of MPP children before treatment was associated with the failure of AZM treatment(OR>1, P<0.05). ROC curve analysis showed that the AUC of IL-8 and SB7-H3 levels in lavage fluid in MPP children before treatment for the risk of failure to azithromycin was greater than 0.80, which was ideal in predicting value. Conclusion: The expression levels of IL-8 and SB7-H3 in lavage fluid of MPP children before treatment were related to the failure of AZM treatment in children, which might be the risk factors for the failure of AZM treatment in children, which had certain value for the prediction of the failure risk of AZM treatment in children.