抗栓治疗消化道损伤的中西医防治研究进展

Advances in prevention and treatment of digestive tract damage induced by antithrombotic therapy with traditional Chinese and Western medicine

随着人口老龄化的加剧,心血管疾病发病率呈明显上升趋势.越来越多的患者需要服用抗栓药物以降低心血管不良事件的发生风险.然而,长期使用抗栓药物可造成消化道损伤,药物相关性消化性溃疡和出血等胃肠道并发症在这类患者中十分常见.为了减少抗栓药物引起的消化道损伤,目前临床上常用的防治策略主要有以下几点:(1)纠正可干预的危险因素;(2)充分考虑心血管获益与胃肠道并发症风险的平衡,选择最适宜的抗栓治疗方案;(3)使用胃黏膜保护剂.近年来,研究人员也尝试从传统中医药中寻找新的防治方案.相关研究表明,中医药在防治消化道损伤方面有其独到之处且临床疗效颇佳.本文就抗栓治疗所致消化道损伤及其中西医防治的最新研究进展作一综述.

The incidence of cardiovascular diseases has increased due to the aging of the population.Therefore,antithrombotic therapy is increasingly prescribed for cardiovascular prevention.However,long-term use of antithrombotic drugs can cause damage to the digestive tract.Gastrointestinal complications,including ulcer and bleeding,are relatively common during antithrombotic therapy.In order to minimize the digestive tract damage induced by antithrombotic drugs,there are several strategies available,including reducing modifiable risk factors,using the most optimal antithrombotic regimen to ensure gastrointestinal risk-cardiovascular benefit balance,and using gastroprotective agents.In recent years,researchers are attempting to find new solutions from traditional Chinese medicine.Studies have shown that traditional Chinese medicine has its own characteristics and clinical advantages in preventing and treating diseases.In this review,we provide a summary of recent updates regarding gastrointestinal damage induced by antithrombotic therapy as well as its prevention and treatment with both traditional Chinese and Western medicine.