长链非编码RNA调控胃癌巨噬细胞极化研究进展

Role of long non-coding RNA in regulating polarization of gastric cancer macrophages

肿瘤相关巨噬细胞(Tumor-associated macrophages,TAMs)是肿瘤微环境重要的组成部分,其在肿瘤组织和远处转移部位均有分布,与肿瘤的进展和预后有关.M2型TAMs可促进肿瘤增殖、侵袭转移、抑制凋亡等肿瘤生物学过程,与肿瘤患者的不良预后明显相关.近年来,长链非编码RNA(long non-coding RNAs,lncRNAs)调控巨噬细胞极化的作用逐渐被揭示,其可通过调控巨噬细胞极化方向来影响肿瘤的发生和发展.研究表明lncRNAs在胃癌巨噬细胞极化过程发挥重要作用,现就相关研究报道进行综述,以期为干预TAMs极化过程抑制胃癌进展的相关研究提供思路.

Tumor-associated macrophages(TAMs)are an important part of the tumor microenvironment.They are distributed in tumor tissues and distant metastatic sites,and are related to tumor progression and prognosis.TAMs M2 can promote tumor biological processes such as tumor proliferation,invasion,and metastasis,and inhibit apoptosis,and are obviously related to the poor prognosis of tumor patients.In recent years,the role of long non-coding RNAs(lncRNAs)in regulating the polarization of macrophages has gradually been revealed,which can affect the occurrence and development of tumors by adjusting the polarization of macrophages.Studies have shown that lncRNAs play an important role in the polarization process of gastric cancer macrophages.This article summarizes the related research reports,hoping to provide ideas for studies that interfere with the polarization process of TAMs to inhibit tumor progression.