基于半开放式微流控芯片的ZnO纳米材料的合成

Synthesis of ZnO Nanomaterials Based on Semi-Open Microfluidic Chip

设计并制备了一种半开放式微流控芯片,通过微通道喷管在邻近区域产生浓度梯度,探究了不同体积流量下的浓度变化,并在该区域合成氧化锌(ZnO)纳米材料。利用扫描电子显微镜(SEM)和X射线衍射仪(XRD)对ZnO纳米材料的形貌和晶体结构进行了表征。结果表明,由于流场和扩散的影响,生长溶液在合成初期会形成显著的浓度梯度,进而在同一芯片的不同区域生长出不同形貌的ZnO纳米材料。此外,在1μL/min体积流量下合成ZnO纳米材料,并对异硫氰酸荧光素标记的羊抗牛免疫球蛋白(FITC-anti bovine IgG)进行了检测。结果表明,基于半开放式微流控芯片的合成方法不仅可以提高优化合成条件的效率,一步合成直径差可达2倍的ZnO纳米材料,也便于研究不同形貌的ZnO纳米材料的荧光检测性能。

A semi-open microfluidic chip was designed and fabricated.Through the concentration gradient in the proximity region generated by the microchannel nozzles,the concentration change under different volume flows was investigated,and zinc oxide(ZnO)nanomaterials were synthesized in the region.The morphology and crystal structure of the ZnO nanomaterials were characterized by scanning electron microscope(SEM)and X-ray diffractometer(XRD).The results show that due to the influences of flow field and diffusion,the obvious concentration gradient is formed in the initial synthesis of the growth solution,and then the ZnO nanomaterials with different morphologies are grown in different regions of the same chip.Besides,the ZnO nanomaterials were synthesized at a volume flow of 1μL/min,and the FITC-labeled goat anti-bovine IgG was detected.The results reveal that the synthesis method based on the semi-open microfluidic chip can improve the efficiency of optimizing the synthesis conditions(ZnO nanomaterials with diameter difference of up to 2 times can be synthesized in one step),and easily study the fluorescence detection performances of ZnO nanomaterials with different morphologies.