Hhip和Lpar2基因表达与胃癌相关性的研究进展

Advances in understanding of relationship between Hhip and Lpar2 gene expression and gastric cancer

胃癌(gastric cancer,GC)是源于胃粘膜上皮细胞的恶性肿瘤,近年来研究表明Hhip与Lpar2基因在GC的发生发展中分别发挥着抑制和促进的作用,Hhip基因通过参与Hh信号通路抑制GC细胞的增殖与侵袭,而Lpar2基因通过激活ATX-LPA信号通路促进GC的发生发展.本文就Hhip与Lpar2基因在GC患者中的表达水平变化、相关分子机制及未来在临床上的应用作一综述.

Gastric cancer(GC)is a malignant tumor derived from gastric mucosal epithelial cells.In recent years,it has been found that the Hhip and Lpar2 genes play an important role in the development of GC.The Hhip gene can inhibit the proliferation and invasion of GC cells by participating in the Hedgehog signaling pathway,while the Lpar2 gene promotes the development of GC by activating the ATX-LPA signaling pathway.In this paper,we will review the changes of expression levels,molecular mechanism,and clinical application of Hhip and Lpar2 genes in GC patients.