P-选择素、促血小板生成素与脑胶质瘤患者病情严重程度的相关性研究

Correlation between P-selectin,thrombopoietin and severity of glioma

目的分析P-选择素、促血小板生成素(TPO)在脑胶质瘤患者表达情况,并探讨其与病情严重程度的相关性。方法选择2017年6月至2019年6月在大连市第三人民医院接受治疗的106例脑胶质瘤患者作为观察组,同期50例医院健康体检的健康者作为健康组。对两组患者的临床资料进行分析。结果观察组患者的血清P-选择素、TPO水平明显高于健康组[(62.35±16.71)μg/L比(25.42±9.18)μg/L、(12.64±3.26)μg/L比(6.93±1.77)μg/L](P<0.01)。在不同严重程度脑胶质瘤患者中,高级别组患者的血清P-选择素、TPO水平明显高于低级别组[(65.14±17.19)μg/L比(53.71±15.26)μg/L、(14.57±3.38)μg/L比(9.04±1.97)μg/L](P<0.01)。脑胶质瘤患者治疗后的血清P-选择素、TPO水平明显低于治疗前[(57.28±16.22)μg/L比(62.35±16.71)μg/L、(10.85±2.97)μg/L比(12.64±3.26)μg/L](P<0.01)。Spearman相关性分析结果显示,脑胶质瘤患者血清P-选择素、TPO水平与WHO分级呈正相关性(r=0.417、0.361,P<0.05)。受试者工作特征曲线分析结果显示,血清P-选择素水平在诊断脑胶质瘤时的曲线下面积(AUC)为0.859(95%CI 0.794~0.910,P<0.01),灵敏度为90.00%,特异度为74.53%;血清TPO水平在诊断脑胶质瘤时的AUC为0.720(95%CI 0.643~0.789,P<0.01),灵敏度为69.81%,特异度为72.00%。结论血清P-选择素、TPO在脑胶质瘤患者中均存在着异常表达的情况,且其水平变化同病情严重程度相关。

Objective To analyze the expression of P-selectin and thrombopoietin(TPO)in patients with glioma,and explore their correlation with severity of disease.Methods One hundred and six patients with glioma who were treated in the Third People's Hospital of Dalian City from June 2017 to June 2019 were selected as the observation group,and 50 physical examination person in the same period were selected as the healthy control group.The clinic data of patients in two groups were analyzed.Results The serum P-selectin and TPO levels in the observation group were significantly higher than those in the healthy control group:(62.35±16.71)μg/L vs.(25.42±9.18)μg/L,(12.64±3.26)μg/L vs.(6.93±1.77)μg/L(P<0.01).In patients with different severity of glioma,serum P-selectin and TPO levels in the high-grade group were significantly higher than those in the low-level group:(65.14±17.19)μg/L vs.(53.71±15.26)μg/L,(14.57±3.38)μg/L vs.(9.04±1.97)μg/L(P<0.01).Serum P-selectin and TPO levels in patients with glioma after treatment were significantly lower than those before treatment:(57.28±16.22)μg/L vs.(62.35±16.71)μg/L,(10.85±2.97)μg/L vs.(12.64±3.26)μg/L(P<0.01).Spearman correlation analysis result showed that there was a significant positive correlation between serum P-selectin,TPO levels and WHO classification in patients with glioma(r=0.417 and 0.361,P<0.05).The results of receiver operating characteristic(ROC)curve analysis showed that the area under curve(AUC)of serum P-selectin in the diagnosis of glioma was 0.859(95%CI 0.794 to 0.910,P<0.01),the sensitivity was 90.00%,and the specificity was 74.53%.The ROC curve analysis result showed that the AUC of serum TPO in the diagnosis of glioma was 0.720(95%CI 0.643 to 0.789,P<0.01),the sensitivity was 69.81%,and the specificity was 72.00%.Conclusions Serum P-selectin and TPO are abnormally expressed in glioma patients,and their level changes are related to the severity of the disease.