脓毒症基础研究的进展及未来方向

Current progress and future directions of basic research on sepsis

脓毒症为机体对感染的反应失调而导致危及生命的器官功能障碍,其发病机制复杂,病死率高。深入开展基础研究是突破脓毒症临床诊疗"瓶颈"的重要途径之一,然而当前基础研究面临异质性高、转化难的困境。因此,本文将着手分析脓毒症基础研究领域当前取得的进展及面临的挑战,并展望未来,细胞功能、能量代谢、微生物群、表观遗传学及脓毒症恢复期等方面或可作为重点研究方向。

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection,of which the pathogenesis is complex and the mortality rate is high.However,current basic research is facing the dilemma of high heterogeneity and difficult translation to clinical practice.In-depth basic research is one of the most important ways to break through the"bottleneck"of clinical diagnosis and treatment of sepsis.The purpose of this review is to analyze the current progress and challenges in the field of basic research on sepsis,and look forward to the potential research directions in the future.Cell function,energy metabolism,microbiota,epigenetics and recovery period of sepsis may be the research priorities.