妊娠期高血压疾病早期肾损伤患者检测血清胱抑素C及尿液肾损伤分子-1的临床意义

Clinical significance of detection of serum cystatin C and urine renal injury molecule-1 in patients with early renal injury in hypertensive disorder complicating pregnancy

目的探讨妊娠期高血压疾病早期肾损伤产妇检测血清胱抑素C(SCys C)、尿液肾损伤分子-1(KIM-1)的临床意义。方法选取2017年1月至12月江西省妇幼保健院收治的30例妊娠期高血压疾病早期肾损伤产妇作为试验组,选取同期30例妊娠期高血压疾病而无肾损的产妇作为对照组,比较两组产妇的尿N-乙酰葡糖胺(NAG)、24 h尿蛋白定量、SCys C、KIM-1水平及不良母婴结局发生率。结果试验组产妇的尿NAG[(8.91±1.24)U/L]、24 h尿蛋白定量[(272.08±26.88)mg]、胱抑素C[(7.05±1.02)mg/L]、KIM-1[(3.26±0.44)μmol/L]均高于对照组[(1.72±0.35)U/L、(118.13±15.39)mg、(0.86±0.12)mg/L、(0.86±0.13)μmol/L],差异有统计学意义(P<0.05)。试验组的不良母婴结局胎儿生长受限、新生儿窒息、新生儿低血糖与呼吸窘迫发生率均高于对照组,差异有统计学意义(P<0.05)。结论SCys C、KIM-1检测对于妊娠期高血压疾病早期肾损伤诊断具有一定价值。

Objective To explore the clinical detection of serum cystatin C(SCys C)and urine renal injury molecule-1(KIM-1)in patients with early renal injury in hypertensive disorder complicating pregnancy.Methods From January to December 2017,30 cases of patients with early renal injury in hypertensive disorder complicating pregnancy admitted to Jiangxi Maternal and Child Health Hospital were selected as the experimental group,30 cases of patients with hypertensive disorder complicating pregnancy during the same period without renal injury were selected as the control group.The urine N-acetylglucosamine(NAG),24 h urine protein quantification,SCys C,KIM-1 and the incidence of adverse maternal and infant outcomes were compared between the two groups.Results Urine NAG([8.91±1.24]U/L),24 h urine protein quantification([272.08±26.88]mg),SCys C([7.05±1.02]mg/L),KIM-1([3.26±0.44]μmol/L)in the experimental group were higher than those in the control group([1.72±0.35]U/L,[118.13±15.39]mg,[0.86±0.12]mg/L,[0.86±0.13]μmol/L),and the differences were statistically significant(P<0.05).The incidence of fetal growth restriction,neonatal asphyxia,neonatal hypoglycemia and respiratory distress in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion SCys C and UKIM-1 levels detection have practical values for the diagnosis of early renal injury in hypertensive disorder complicating pregnancy.