血清降钙素原、白介素6、C反应蛋白表达与慢性支气管炎患者肺功能的相关性分析

Correlation analysis between the expression of procalcitonin, interleukin-6, C-reactive protein and pulmonary function in patients with chronic bronchitis

目的探讨降钙素原(PCT)、白介素6(IL-6)、C反应蛋白(CRP)的表达与慢性支气管炎患者肺功能的关系。方法回顾性分析2018年10月至2020年10月济南市长清区人民医院诊治的79例慢性支气管炎患者的临床资料,按照病情进展将其分为急性加重期组(41例)与缓减期组(38例),并选取同期的30例健康体检者作为对照组。比较三组的血清PCT、IL-6、CRP水平及相关肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)和最大通气量(MVV)],并进行相关性分析。结果三组的PCT、IL-6、CRP水平整体比较,差异有统计学意义(P<0.05);急性加重期组、缓减期组患者的PCT、IL-6、CRP水平高于对照组,差异有统计学意义(P<0.05);急性加重期组患者的PCT、IL-6、CRP水平高于缓减期组,差异有统计学意义(P<0.05)。三组的FVC、FEV1和MVV水平整体比较,差异有统计学意义(P<0.05);急性加重期组、缓减期组患者的FVC、FEV1、MVV水平低于对照组,差异有统计学意义(P<0.05);急性加重期组患者的FVC、FEV1、MVV水平低于缓减期组,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,慢性支气管炎患者的PCT、IL-6、CRP水平与肺功能指标FVC、FEV1、MVV水平成负相关(r=-0.693、-0.724、-0.738,P<0.05)。结论慢性支气管炎患者的PCT、IL-6、CRP水平与肺功能指标FVC、FEV1、MVV具有相关性,可以为临床治疗及病情监测提供参考。

Objective To investigate the relationship between the expression of procalcitonin(PCT),interleukin 6(IL-6),C-reactive protein(CRP)and pulmonary function in patients with chronic bronchitis.Methods Clinical data of 79 patients with chronic bronchitis in Changqing District People′s Hospital of Jinan City from October 2018 to October 2020 were retrospectively analyzed.According to the progress of the disease,they were divided into the acute exacerbation group(41 cases)and the remission group(38 cases).A total of 30 healthy people in the same period were selected as the control group.The serum PCT,IL-6,CRP levels and related pulmonary function indexes such as the forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and maximum ventilation volume(MVV)were compared among the three groups,and the correlation analysis was carried out.Results There were statistically significant differences in the levels of PCT,IL-6 and CRP among the three groups(P<0.05).The levels of PCT,IL-6 and CRP in the acute exacerbation group and the remission group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of PCT,IL-6 and CRP in the acute exacerbation group were higher than those in the remission group,and the differences were statistically significant(P<0.05).There were statistically significant differences in the FVC,FEV1 MVV among the three groups(P<0.05).The levels of FVC,FEV1 and MVV in the acute exacerbation group and the remission group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of FVC,FEV1 and MVV in the acute exacerbation group were lower than those in the remission group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the levels of PCT,IL-6 and CRP were negatively correlated with FVC,FEV1 and MVV(r=-0.693,-0.724,-0.738,P<0.05).Conclusion The levels of PCT,IL-6 and CRP in patients with chronic bronchitis are correlated with FVC,FEV1 and MVV,which can provide reference for clinical treatment and disease monitoring.