疾病的干细胞基础

Stem cell basis of disease

胚胎期特异胚胎细胞分化发育构筑特定功能组织器官时出现变异;在成熟过程中,由组织器官内的成体干细胞分化及重塑发育为成熟组织器官时出现变异;成体内成体干细胞分化及重塑维持特定功能的组织器官时发生变异;在成年个体内成体干细胞分化及重塑并维持正常组织器官内细胞数量和功能,当成体干细胞自我更新减弱与分化能力减弱,可导致功能细胞的形成减少,不能满足组织器官功能的需要,导致相应组织器官的功能衰竭;这些组织器官变异均导致非营养不良和非外因损伤性疾病。

Variation occurs during the differentiation and development of specific embryonic cells to construct specific functional tissues and organs.In the process of maturation,there are variation of mature organelles formed by differentiation and remodeling of adult stem cells in tissues and organs,differentiation and remodeling of adult stem cells in adult individuals is capable to cause the architectural variation of tissues and organs.Adult stem cells differentiate and remodel in adult individuals,and maintain the number and function of cells in normal tissues and organs.The weakening of self-renewal and differentiation of somatic stem cells can lead to the reduction of the formation of functional cells,which can’t meet the needs of tissue and organ function,resulting in the functional failure of corresponding tissues and organs.These tissue and organ variations lead to non malnutrition and non external injury diseases.