光遗传学技术在缺血性脑卒中研究中的应用

Application of optogenetic technology in the study of ischemic stroke

光遗传学技术整合了光学和遗传学,能够利用光特异地在时间及空间两方面精确控制细胞的活性。越来越多的研究证明光遗传学在理解脑未知的组织功能,以及中枢神经系统疾病的治疗方面有巨大的潜力。缺血性脑卒中是常见的脑血管疾病,死亡率、致残率高。光遗传学对于部分特定的脑区、神经回路及神经元的调控能够有效地促进缺血性脑卒中后神经功能的恢复。该综述简单地介绍了光遗传学技术的原理,总结了近年光遗传学技术在缺血性脑卒中研究中的应用情况。

Optogenetic technology,integrating optics and genetics,can utilize light toprecisely control cell viability in time and space.More and more studies have demonstrated the great potential of optogenetics in understanding the unknown tissue functions of the brain and in the treatment of central nervous system diseases.Ischemic stroke is a common cerebro⁃vascular disease,with characteristics of high mortality rate and high disability rate.The regulation of optogenetics on some specific brain regions,neural circuits,and neurons can effectively promote the recovery of neurological function after isch⁃emic stroke.This article reviews the principle of optogenetic technology and the application of optogenetic technology in the study of ischemic stroke in recent years.