基于层层自组装多层膜的耐用性超滑导管制备

Robust Lubricant-Infused Slippery Medical Catheters Based on Layer-by-Layer Assembled Multilayers

利用支化聚乙烯亚胺(BPEI)和二氧化硅纳米颗粒–倍半硅氧烷(SiSQ)之间的氢键相互作用,通过层层自组装交替沉积技术分别在硅片和医用导管表面制备了基于40 nm和80 nm二氧化硅纳米颗粒的(BPEI/SiSQ)_(n)多孔多层膜,并通过低黏度硅油多孔灌注的方法制备了ST/(BPEI/SiSQ)_(n)-SO超滑硅胶导管。利用扫描电子显微镜对二氧化硅纳米颗粒和层层自组装多层膜分别进行形貌表征,通过傅里叶变换红外光谱对不同样品进行化学成分分析,证明了(BPEI/SiSQ)_(n)和(BPEI/SiSQ)_(n)-SO涂层的成功制备。另外,以硅片为基底的Si/(BPEI/SiSQ)_(n)-SO水滴接触角和滑动角测量数据分别为104°和4°左右,表明其具有良好的超滑性能。对ST/(BPEI/SiSQ)_(n)-SO超滑导管进行了稳健性测试,包括机械性、化学腐蚀和抗污染测试,展现了稳定的超滑性能。

Herein,hydrogen boning interaction between branched polyethyleneimine(BPEI)and silica nanoparticle-silsesqui-oxane matrix(SiSQ)has been used as the driving force for assembling porous layer-by-layer multilayers on silicon wafer and medical catheter substrates,using 40 nm or 80 nm silica nanoparticles as building blocks.Then,slippery ST/(BPEI/SiSQ)_(n)-SO catheters were prepared by infusing silicone oil with low viscosity into porous ST/(BPEI/SiSQ)_(n).In the present work,the surface morphol-ogy for silica nanoparticles and layer-by-layer assembled multilayers was characterized by scanning electron microscopy(SEM)while chemical analysis was conducted by Fourier transform infrared spectroscopy(FTIR),which indicates successful preparation of(BPEI/SiSQ)_(n)and(BPEI/SiSQ)_(n)-SO coatings.In addition,water contact angle and sliding angle are about 104°and 4°,which are measured on Si/(BPEI/SiSQ)_(n)-SO based on silicon wafer substrate,indicating a good slippery property.At last,the robustness of slippery ST/(BPEI/SiSQ)_(n)-SO catheters was examined,involving mechanical damage,chemical corrosion,and fouling tests.Therefore,an excellent slippery performance is demonstrated on ST/(BPEI/SiSQ)_(n)-SO catheters.