能量代谢在成骨和破骨细胞中的研究

The investigation of energy metabolism in osteoblasts and osteoclasts

骨稳态的维持对于骨骼健康极为重要,如果骨形成与骨吸收的平衡被打破,容易造成骨量丢失、骨质疏松等多种骨骼疾病。近期越来越多的研究表明,能量代谢失调,例如葡萄糖代谢异常、氨基酸代谢受阻以及脂代谢缺陷等等,都会对骨稳态的平衡造成破坏,从而引起或是加剧导致骨量减少和骨质疏松性骨折等疾病。本文将对能量代谢在成骨细胞以及破骨细胞中的研究进展进行总结分析,深入了解能量代谢,特别是葡萄糖代谢在骨稳态维持中对成骨、破骨细胞分化和功能的关键调控作用,为了解、治疗骨质疏松等骨相关疾病提供指导。

The maintenance of bone homeostasis is critical for bone health.It is vulnerable to cause bone loss,even severely osteoporosis when the balance between bone formation and absorption is interrupted.Growing evidence has shown that energy metabolism disorders,such as abnormal glucose metabolism,irregular amino acid metabolism,and ab‐errant lipid metabolism,can damage bone homeostasis,causing or exacerbating bone mass loss and osteoporosis-related fractures.Here,we summarize the studies of energy metabolism in osteoblasts and osteoclasts and provide a better appre‐ciation of how energy metabolism,especially glucose metabolism maintains bone homeostasis.With this knowledge,new avenues will be unraveled to understand and cue bone-related diseases such as osteoporosis.