盐酸丁螺环酮联合重复经颅磁刺激对慢性精神分裂症患者阴性症状及认知功能的影响

Effects of buspirone hydrochloride combined with repeated transcranial magnetic stimulation on negative symptoms and cognitive function in patients with chronic schizophrenia

目的探讨盐酸丁螺环酮联合重复经颅磁刺激治疗慢性精神分裂症患者的疗效及对患者阴性症状、认知功能的影响。方法将80例慢性精神分裂症患者按照随机数字表法分为研究组与对照组,各40例,两组均给予盐酸丁螺环酮治疗,研究组在此基础上给予重复经颅磁刺激治疗,观察1个月。比较两组临床疗效,治疗前后采用阴性症状评定量表评定两组阴性症状,蒙特利尔认知评估量表评定两组认知功能,生活质量综合评定量表评定两组生活质量,比较两组不良反应发生率。结果研究组治疗总有效率显著高于对照组(P<0.05)。治疗后两组阴性症状评定量表评分均较治疗前显著降低(P<0.01),蒙特利尔认知评估量表评分均较治疗前显著升高(P<0.01),研究组较对照组变化更显著(P<0.01)。治疗后两组生活质量综合评定量表各项评分均较治疗前显著升高(P<0.01),研究组较对照组升高更显著(P<0.05或0.01)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论盐酸丁螺环酮联合重复经颅刺激治疗慢性精神分裂症效果显著,能有效改善患者的阴性症状及认知功能,提高生活质量,安全性高。

Objective To investigate the efficacy of buspirone hydrochloride combined with repeated transcranial magnetic stimulation in the treatment of patients with chronic schizophrenia,and its influence on patients'negative symptoms and cognitive function.Methods A total of 80 patients with chronic schizophrenia were randomly divided into study group and control group,with 40 cases in each group.Both groups were treated with buspirone hydrochloride,and the study group was treated with repeated transcranial magnetic stimulation for 1 month.The clinical effects of the two groups were compared.Before and after treatment,the negative symptoms of the two groups were assessed by scale for assessment of negative symptoms(SANS),the cognitive function of the two groups was assessed by Montreal cognitive assessment(MoCA),and the quality of life of the two groups was assessed by generic quality of life inventory-74(GQOLI-74).The incidence of adverse reactions was compared between the two groups.Results The total effective rate in study group was significantly higher than that in control group(P<0.05).After treatment,the SANS scores of the two groups were significantly lower than those before treatment(P<0.01),and the MoCA scores were significantly higher than those before treatment(P<0.01).The changes of the study group were more significant than those of the control group(P<0.01).After treatment,the scores of GQOLI-74 in the two groups were significantly higher than those before treatment(P<0.01).The increase in the study group was more significant than that in the control group(P<0.05 or 0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Buspirone hydrochloride combined with repeated transcranial magnetic stimulation has a significant effect on the treatment of chronic schizophrenia,which can effectively improve the patient's negative symptoms and cognitive function,improve the quality of life,with high safety.