rt-PA静脉溶栓联合银杏达莫注射液治疗急性脑梗死临床疗效

Clinical effect of rt-PA intravenous thrombolysis combined with Ginkgo dipyridamole injection in the treatment of acute cerebral infarction

目的探讨阿替普酶静脉溶栓联合银杏达莫注射液治疗急性脑梗死患者的临床疗效。方法将88例急性脑梗死患者按照随机数字表法分为研究组与对照组,各44例。两组均给予基础治疗,给予阿替普酶静脉溶栓,研究组在此基础上给予银杏达莫注射液治疗,观察2周。结果研究组治疗总有效率显著高于对照组(P<0.05)。治疗后两组大脑前动脉、大脑中动脉、大脑后动脉平均血流速度均显著高于治疗前(P<0.01),研究组显著高于对照组(P<0.01);两组血浆内皮素-1水平均显著低于治疗前(P<0.01),一氧化氮水平均显著高于治疗前(P<0.01),研究组较对照组变化更显著(P<0.01);两组美国国立卫生研究院卒中量表及改良Rankin量表评分均显著低于治疗前(P<0.01),研究组显著低于对照组(P<0.01)。结论阿替普酶静脉溶栓联合银杏达莫注射液治疗急性脑梗死患者疗效显著,可提高患者脑血流速度,降低血浆内皮素-1水平,提高血浆一氧化氮水平,减少神经功能损伤,改善预后。

Objective To investigate the clinical effect of alteplase(rt-PA)intravenous thrombolysis combined with Ginkgo dipyridamole injection in the treatment of acute cerebral infarction(ACI).Methods A total of 88 patients with ACI were divided into study group and control group according to random number table method,with 44 cases in each group.Both groups were given basic treatment and rt-PA intravenous thrombolysis.On this basis,the study group was given Ginkgo dipyridamole injection for 2 weeks.Results The total effective rate in study group was significantly higher than that in control group(P<0.05).After treatment,the mean blood flow velocity of anterior cerebral artery(ACA),middle cerebral artery(MCA)and posterior cerebral artery(PCA)in the two groups were significantly higher than those before treatment(P<0.01).The plasma endothelin-1(ET-1)levels in both groups were significantly lower than those before treatment(P<0.01),and the levels of nitric oxide(NO)in both groups were significantly higher than those before treatment(P<0.01).The change of study group was more significant than that of control group(P<0.01).The National Institutes of Health Stroke Scale(NIHSS)and modified Rankin scale(mRS)scores in both groups were significantly lower than those before treatment(P<0.01),and those in the study group were significantly lower than those in the control group(P<0.01).Conclusions Alteplase intravenous thrombolysis combined with Ginkgo dipyridamole injection has a significant effect in the treatment of ACI patients.It can increase the cerebral blood flow velocity,reduce plasma ET-1 level,increase plasma NO level,reduce nerve function damage and improve the prognosis.