胰腺癌循环肿瘤细胞检测技术及临床应用前景

Detection Technology and Prospects of Clinical Application of Circulating Tumor Cells in Pancreatic Cancer

胰腺癌是消化系统高度恶性的肿瘤之一,其早期即可发生远处转移,患者生存期较短、预后较差。循环肿瘤细胞(circulating tumor cells,CTCs)是一类可进入血液循环的肿瘤细胞,不仅具有与原发肿瘤细胞相似的特征,且与肿瘤远处转移的关系更为密切。体外定量检测CTCs对胰腺癌的早期诊断、辅助分期、疗效及预后评估均具有重要意义。本文对胰腺癌CTCs富集方法及CTCs检测在胰腺癌筛查、远处转移与预后评估中的应用进行综述。

Pancreatic cancer is one of the highly malignant tumors of the digestive system,and early metastasis is an important reason for its short survival time.Circulating tumor cells(CTCs)are a type of tumor cells that are released into the bloodstream from the primary tumor and/or metastatic sites,which have properties similar to primary tumor cells and are closely related to distant metastasis of tumors.In vitro quantitative detection of CTCs is of great significance in the early diagnosis,auxiliary staging,treatment efficacy,and prognosis evaluation of pancreatic cancer.Here we generally reviewed current research on the CTCs enrichment methods of pancreatic cancer and its application in screening pancreatic cancer and metastasis,and evaluating the prognosis.