地中海饮食通过抗氧化应激抑制动脉粥样硬化血栓形成

Mediterranean Diet Inhibition of Atherosclerotic Thrombosis through Anti-oxidative Stress

动脉粥样硬化斑块破裂和血栓形成是心肌梗死的主要发病机制,其中血栓形成主要通过血小板激活及凝血级联反应完成。而氧化应激可促进动脉粥样硬化、血小板聚集及凝血级联反应,故氧化应激参与了心肌梗死的病理生理过程。地中海饮食模式有利于降低心肌梗死发生率,其可能的机制为地中海饮食模式中的营养物质通过延缓动脉粥样硬化、抗血栓形成进而对心血管形成保护作用,这可能与这些营养物质的抗氧化应激作用有关,但具体机制尚不清楚。因此,对相关机制进行深入研究可能能为动脉粥样硬化疾病的预防、治疗和后期康复提供新思路。

Atherosclerotic plaque rupture and thrombosis are the main pathogenesis of myocardial infarction,and thrombosis is mainly completed by platelet activation and coagulation cascade.Oxidative stress can promote atherosclerosis,platelet aggregation and coagulation cascade,so it is involved in the pathophysiological process of myocardial infarction.The Mediterranean diet is conducive to reducing the incidence of myocardial infarction.The possible mechanism is that the nutrients in the Mediterranean diet can delay atherosclerosis,resist thrombosis and then protect the cardio vessles,and this may be related to the antioxidant of these nutrients,although the specific mechanism is not clear.Therefore,further studies on the specific mechanism of anti-oxidative stress affecting atherosclerosis and thrombosis may provide new ideas for the prevention,treatment and prognosis of atherosclerotic diseases.