非编码RNA在结直肠癌早期诊断中的应用

Application of non-coding RNAs in early diagnosis of colorectal cancer

非编码RNA(ncRNA)是一类不具有编码蛋白质功能的RNA。近年来越来越多的研究结果显示结直肠癌(CRC)的发生发展与ncRNA的异常表达密切相关,可作为一种无创性检测生物标志物用于CRC的早期诊断。对目前ncRNA在CRC早期诊断中的研究进展进行综述,总结ncRNA检测的潜在临床价值,可为提高CRC的早期诊断率提供理论依据。

Non-coding RNAs(ncRNAs)is a kind of RNA without protein coding function.A large number of studies in recent years have shown that the occurrence and development of colorectal cancer(CRC)are closely related to the aberrant expression of ncRNAs.ncRNAs can be used as non-invasive biomarkers for early diagnosis of CRC.We review the research progress of ncRNAs in early diagnosis of CRC,and summarize the potential clinical value of ncRNAs detection,which can provide a theoretical basis for improving the early diagnosis rate of CRC.