表没食子儿茶素没食子酸酯对雌性生殖系统作用的研究进展

Research progress of role of catechin EGCG on female reproductive system

表没食子儿茶素没食子酸酯(EGCG)是一种多酚类物质,各类茶叶中在绿茶中含量最高,是一种具备广谱抗氧化性、抗炎性、抗肿瘤性质、促进代谢和血管生成活性的儿茶素。大量研究证明儿茶素EGCG与生殖系统的生理和病理调控密切相关,可抵抗氧化应激损伤,具有改善配体发育等作用。现就儿茶素EGCG在调节女性生殖系统类固醇激素合成、改善卵母细胞成熟和胚胎质量的作用进行综述,为生殖系统疾病的治疗提供新的思路。

Epigallocatechin gallate(EGCG)is a kind of polyphenol.The content of EGCG in green tea is the highest among all kinds of tea.It is a catechin with broad-spectrum antioxidant,anti-inflammatory,anti-tumor properties and can promote metabolism and angiogenesis.A large number of studies have proved that EGCG is closely related to the physiological and pathological regulation of the reproductive system.EGCG can reduce oxidative stress and has an effect on germ maturation and development.This paper summarized the role of EGCG in regulating steroid hormone synthesis in female reproductive system and improving oocyte maturation and embryo quality,in order to provide new ideas for the treatment of reproductive system diseases.