慢性阻塞性肺疾病患者血清可溶性基质裂解素2、白细胞介素-33水平及其与疾病严重程度的关系研究

Study on the relationship between serum sST2 and IL-33 levels in patients with chronic obstructive pulmonary disease and the severity of the disease

目的分析慢性阻塞性肺疾病(COPD)患者血清s ST2、IL-33水平及其与疾病严重程度的关系。方法选定本院2018年7月—2020年7月住院治疗的100例COPD患者作为观察组,以及同期门诊体检的100例健康者作为对照组,检测对比2组血清s ST2、IL-33水平,对比观察组不同病情严重程度组血清s ST2、IL-33水平、CAP评分,对比急性加重期、稳定期组血清s ST2、IL-33水平、CAP评分,Speraman相关分析血清s ST2、IL-33水平与CAP评分关系。结果观察组血清s ST2、IL-33水平均低于对照组(P<0.05)。极重度组血清s ST2、IL-33水平均高于重度组,重度组血清s ST2、IL-33水平高于中度组,中度组血清s ST2、IL-33水平高于轻度组,极重度组CAP评分低于重度组,重度组CAP评分低于中度组,重度组CAP评分低于轻度组,差异均有统计学意义(P<0.05)。急性加重期组血清s ST2、IL-33水平均高于稳定期组,CAP评分低于稳定期组(P<0.05)。血清s ST2、IL-33水平与CAP评分呈负相关性(t值分别为-0.418、-0.529,P<0.01)。结论COPD患者机体血清s ST2、IL-33水平普遍呈高表达状态,两者与CAP评分(病情严重程度)呈正相关性。

Objective To analyze the serum sST2 and IL-33 levels in patients with chronic obstructive pulmonary disease(COPD)and their relationship with the severity of the disease.Methods One hundred COPD patients who were hospitalized in our hospital from July 2018 to July 2020 were selected as the observation group,and 100 healthy people who received outpatient physical examination during the same period were selected as the control group.The serum sST2 and IL-33 levels of the two groups were tested and compared.The serum sST2,IL-33 and CAP scores of the observation group were compared in different severity groups,and the serum sST2,IL-33 and CAP scores of the acute exacerbation and stable phase groups were compared.Speraman correlation analysis was performed on the relationship between serum sST2 and IL-33 levels and CAP scores.Results The levels of serum sST2 and IL-33 in observation group were lower than those in control group(P<0.05).The serum sST2 and IL-33 levels of the extremely severe group were higher than those of the severe group,the serum sST2 and IL-33 levels of the severe group were higher than those of the moderate group,and the serum sST2 and IL-33 levels of the moderate group were higher than those of the mild group.The CAP score of the extremely severe group was lower than that of the severe group,and the CAP score of the severe group was lower than that of the moderate group.The CAP score of severe group was lower than that of mild group,with the difference statistically significant(P<0.05).The serum levels of sST2 and IL-33 in the acute exacerbation group were higher than those in the stable group,and the CAP score was lower than that in the stable group(P<0.05).The levels of SERUM sST2 and IL-33 were negatively correlated with CAP score(t=-0.418,t=-0.529,P<0.01).Conclusion The serum sST2 and IL-33 levels of COPD patients are generally and highly expressed,and the two are positively correlated with the CAP score(severity of the disease).