基于中医传承辅助平台分析《中华人民共和国药典》治疗失眠中成药的用药规律

Analysis on medication rules of Chinese patent medicine for insomnia in Chinese Pharmacopoeia Based on TCM Heritage Supporting Platform

目的通过“中医传承辅助平台(V2.5)”(以下简称“辅助平台”)软件分析《中华人民共和国药典2020年版:一部》(以下简称《中国药典》)收录的治疗失眠中成药的用药规律,为临床治疗失眠组方用药提供思路和借鉴。方法收集《中国药典》中治疗失眠的中成药,根据其功能、主治分为两类,借助于辅助平台对两类处方的证候、用药频次、四气、五味及归经情况分别进行统计,并分析组方规律,进行新方分析。结果功能记载有安神并且主治明确针对失眠的处方,录入41首,包含26个证型,包含中药145味,共计用药频次405次,以补虚药和安神药为主;性味以甘、温为主,主要入肝、心经;常用中药以酸枣仁为核心,当归、远志、茯苓、五味子使用较多,当归、酸枣仁、远志3味药的关联度高;新方分析得到4个处方,可分别用于肝肾阴虚、阴阳两虚、气阴两虚、心脾两虚证的治疗。功能未记载安神但主治中明确能治疗失眠的处方,录入24首,包含21个证型,包含中药92味,共计用药频次181次,以补虚药、活血药和清热药为主;性味以甘、温为主,主要入肝、肾经;常用中药以黄芪、当归为核心,白芍、何首乌、淫羊藿、川芎、熟地黄使用较多,当归、川芎、熟地黄3味药的关联度高;新方分析得到1个处方,可用于血瘀型失眠的治疗。结论辅助平台能客观呈现《中国药典》中关于失眠的用药规律,指导临床治疗失眠。

Objective Analyze the medication rules of Chinese patent medicine for insomnia in Pharmacopoeia of the People's Republic of China(2020 edition)through TCM Heritage Supporting Platform(V2.5),so as to provide ideas and reference for insomnia.Methods Chinese patent medicines for insomnia in Chinese Pharmacopoeia(2020 edition)were collected and divided into two categories according to their functions and indications.The syndromes,frequency of medications,four properties,five flavors and channel tropism of the two types of prescriptions were separately counted,as well as the Formula of TCM and new prescriptions were analyzed with the aid of TCM Heritage Supporting Platform.Results 41 insomnia prescriptions of functions with calming the mind including 26 syndromes,145 kinds of traditional Chinese medicines were used 405 times,mainly tonic medicine and sedative drugs.The properties and flavors are mainly sweet and warm,channel tropism mainly in Liver and Heart.The frequently-used Chinese medicines are Ziziphi spinosae semen,Angelicae sinensis radix,Polygalae radix,Poria and Schisandrae chinensis fructus,focus on Ziziphi spinosae semen.Angelicae sinensis radix,Ziziphi spinosae semen and Polygalae radix are highly related.The new prescription analyzing resulted in 4 prescriptions,which can be used for the treatment of Yin deficiency of liver and kidney,deficiency of both Yin and Yang,deficiency of both Qi and Yin,and deficiency of both heart and spleen.24 insomnia prescriptions of functions without calming the mind including 21 syndromes,92 kinds of traditional Chinese medicines were used 181 times,mainly activating blood circulation and Clearing away heat.The properties and flavors are mainly sweet and warm,channel tropism mainly in Liver and Kidney.The frequently-used Chinese medicines are Astragali radix,Angelicae sinensis radix,Paeoniae radix alba,Polygoni multiflori radix,Epimedium,Chuanxiong rhizoma and Rehmanniae radix praeparata,focus on Astragali radix and Angelicae sinensis radix,Angelicae sinensis radix,Chuanxiong rhizoma and Rehmanniae radix praeparata are highly related.The new prescription analyzing resulted in 1 prescriptions,which can be used for the treatment of insomnia with blood stasis syndrome.Conclusion The medication rules of insomnia in Chinese Pharmacopoeia can objectively present by TCM Heritage Supporting Platform,which plays a guiding role in the clinical treatment of insomnia.