人乳头瘤病毒感染的多因素分析及与阴道微生态的相关性

Multivariate analysis of HPV infection and the correlation with microecology

目的探讨影响人乳头瘤病毒(HPV)感染的因素及与阴道微生态之间的相关性。方法选取2019年5月至2020年1月上海交通大学医学院附属苏州九龙医院就诊的300例育龄期女性作为研究对象,根据HPV筛查结果分为HPV阳性组(n=150)和HPV阴性组(n=150)。通过比较基本资料、阴道分泌物指标,分析HPV感染的高危因素及与阴道微生态指标的相关性。结果两组孕产次、性生活频率、性伴侣个数、初次性生活年龄、学历、阴道pH、阴道清洁度、细菌性阴道炎(BV)患病率及微生态指标过氧化氢(H_(2)O_(2))、唾液酸苷酶(SNa)比较,差异具有统计学意义(P<0.05);两组初潮年龄、月经情况、个人收入,霉菌性阴道炎(VVC)、滴虫性阴道炎(TV)、衣原体感染情况,白细胞脂酶(LE)水平分布比较,差异无统计学意义(P>0.05)。结论积极治疗阴道感染、保持阴道微生态平衡可降低HPV感染概率。

Objective To investigate the risk factors of HPV infection and the correlation between HPV infection and vaginal microecology.Methods 300 women of reproductive age treated in Suzhou Kowloon Hospital from May 2019 to January 2020 were selected and divided into HPV positive group(n=150)and HPV negative group(n=150)according to HPV screening results.The risk factors of HPV infection and their correlation with microecological indicators were analyzed by comparing basic data and vaginal secretions.Results There were statistically significant differences between the two groups in terms of number of pregnancy,frequency of sexual life,number of sexual partners,age of first sexual life,educational background,vaginal pH,vaginal cleanliness,bacterial vaginitis(BV)and microecological indicators such as H_(2)O_(2) and SNa(P<0.05).There were no significant differences in menarche age,menstrual status,personal income,VVC,TV,chlamydia infection and LE level between the two groups(P>0.05).Conclusions Active treatment of vaginal infection and maintenance of vaginal microecological balance can reduce the probability of HPV infection.