响应面法优化超声辅助酯交换合成月桂酸单甘油酯

Optimization of Ultrasonic-assisted Transesterification for Synthesis of Glyceryl Laurate by Response Surface Methodology

在无溶剂的条件下,以月桂酸乙酯和甘油为原料,无水K2CO3为催化剂,超声辅助酯交换合成月桂酸单甘油酯。通过研究超声功率、反应温度和反应时间对总产率的影响,并选用响应面软件中的Box-Behnken方法优化反应工艺,考察月桂酸单甘油酯的产率变化。结果表明,最优反应工艺为反应温度为111.9℃、超声功率为456 W、反应时间68.5min。在此条件下,月桂酸单甘油酯的产率达52%,与预测值无显著性差异,说明超声强化的合成方法可以明显提高反应速率,合成的绿色经济也达到了最大化,符合绿色化学的理念和发展趋势。

The synthesis of glycerol monolaurate(GML)was based on the K2CO3-catalyed ultrasonic-assisted transesterification of ethyl laurate-glycerol in solvent free system.The effects of ultrasonic power,reaction temperature and reaction time on the total yield were systematically studied by single factor experiment.The BoxBehnken Design method in response surface software was used to optimize the reaction process and investigate its change of the yield of GML.The results showed that the optimum reaction conditions were as follows:111.9℃of reaction temperature,456 W of ultrasonic power,and 68.5 min of reaction time.Under these conditions,the yield of monoglyceride laurate reached 52%,which was not significantly different from the predicted value,indicating that the synthesis method of ultrasonic-assisted intensification could greatly improve the reaction rate,and the green economy of synthesis was remarkable,which was also consistent with the concept and development trend of green chemistry.