体表机制:中药外治机制新思考

Mechanism of the body surface:New thinking on the mechanism of traditional Chinese medicine external treatment

中药外治机制研究较少,已有具体单个病外用作用机制的相关报道,而对中药外用共性机制研究鲜见。经皮吸收、经络腧穴学说为常见的外治机制学说,但有一定局限性。皮肤是外周的神经-内分泌-免疫器官,与中枢神经系统具有相同的神经外胚层来源,拥有与中枢神经系统相似的下丘脑-垂体-肾上腺(HPA)系统,能够分泌激素、细胞因子、免疫因子等,机体的中枢神经-内分泌-免疫网络(NEI)与外源的NEI互通,从而发挥抑制或激发作用,调控皮肤发生疾患与否。基于前期大量研究,文章提出中药外治的“体表机制”学说,即中药外用通过三微(局部微作用、微刺激、微吸收)的方式,调节体表-体内NEI网络的紊乱,达到新的平衡,促使疾病趋于康复。

There are few studies on the mechanism of traditional Chinese medicine(TCM)external treatment,and the literature studies have found that there are specific reports on the mechanism of single disease external use,while there are few studies on the common mechanism of TCM external use.The theory of transdermal absorption and meridian points is a common theory of external treatment mechanism,but it has some limitations.Skin is peripheral nerve-endocrine-immune organs,with the central nervous system with the same neural ectoderm origin,and it have similar to the central nervous system of the hypothalamus-pituitary-adrenal(HPA)systems,it could secrete the hormones,cytokines,immune factors,and so on,the body’s central neuroendocrine-immunoregulatory(NEI)network was communication with the exogenous of NEI,so as to play the role of inhibition or inspire,and it regulate the occurrence of skin disorders.Based on a large number of studies in the early stage,our research group proposed the theory of‘mechanism of the body surface’of TCM external treatment,that is the external use of TCM through the way of three micro(local micro effect,micro stimulation and micro absorption),and achieves a new balance by regulating the disorder of the surplus-internal NEI network,so as to promote the recovery of the disease.