基于转移前微环境探讨结直肠癌核心病机生物学基础

Discussion on the biological basis of the core pathogenesis of colorectal cancer based on pre-metastasis niches

肿瘤转移是导致恶性肿瘤难治和病死的主要原因,转移前微环境(PMNs)的形成为肿瘤转移营造了适宜的环境,因此识别和靶向PMNs中的关键因子可有效抑制肿瘤转移。癌毒病机理论认为“湿热瘀毒,脾气亏虚”是结直肠癌发生转移的核心病机。通过探讨结直肠癌的核心病机与PMNs的相关性,阐明PMNs可能是结直肠癌核心病机的生物学基础,进一步揭示结直肠癌核心病机的科学内涵,为临床运用癌毒病机理论辨治肠癌转移提供科学依据。

Tumor metastasis is the main cause of refractory and death of malignant tumor.The formation of premetastasis niches(PMNs)creates a suitable environment for tumor metastasis,therefore,the identification and targeting of key factors in PMNs can effectively inhibit tumor metastasis.The pathogenesis theory of cancer toxin holds that‘damp-heat and blood stasis,spleen-qi deficiency’is the core pathogenesis of colorectal cancer metastasis.By discussing the correlation between the core pathogenesis of colorectal cancer and the PMNs,this paper clarifies that the PMNs may be the biological basis of the core pathogenesis of colorectal cancer,and further reveals the scientific connotation of the core pathogenesis of colorectal cancer.To provide scientific basis for clinical application of cancer toxin pathogenesis theory in the diagnosis and treatment of colorectal cancer metastasis.