摘要
目的:探讨变应性鼻炎(A R)中医体质调护的临床疗效。方法:采用实效性随机对照试验(PRCT),选取278例AR患者随机分为试验(A)组、对照(B)组。两组均行阶梯化西药治疗4~8周,A组同时行中医体质辨识并予中医体质调护。治疗前及治疗后4、8、24周比较两组患者AR症状VAS评分、药物积分变化。结果:自身前后纵向对照,两组VAS评分及药物积分均较干预前改善(P<0.05);组间横向比较,前3个时间点两组变化大致相同,治疗后24周A组改善优于B组,重复测量方差分析提示“时间*分组”交互作用:FVAS=6.55,PVAS<0.001;F药物积分=5.04,P药物积分=0.002,说明A组VAS评分及药物积分的长期疗效优于B组。结论:单纯西药治疗AR短期疗效明显,中医体质调护能持续促进和维持AR症状改善、减少药物使用。
Objective:To investigate the clinical effect of identification of intervention of TCM constitution treatment for allergic rhinitis(AR).Methods:This was a pragmatic randomized controlled trial.A total of 278 patients with AR were randomized into the TCM constitution and conventional medicine group(Group A)or conventional group(Group B).Two groups received stepped pharmacotherapy according the severity of allergic rhinitis for 4 to 8 weeks.Besides the pharmacotherapy,comprehensive treatments based on TCM constitution identification were also given to Group A.The symptoms of AR based on visual analogue scale(VAS)and medication scores(MS)in two groups were campared before the treatment and 4,8,24 weeks after the treatment.Results:Vertical comparision:the VAS and medication scores of the two groups were increased after the treatment(P<0.05).Horizontal comparision:Similar variation tendency could be observed in the two groups on the first 3 time points.24 weeks after treatment,group A was better than group B,repeated measurement analysis of variance pointed out that‘time*group’were interaction,FVAS=6.55,PVAS<0.001;FMS=5.04,PMS=0.002,which indicated a superior long term effect of VAS and medication scores in Group A than Group B.Conclusion:It shows a significant short term effect of pharma cotreatment for AR.The identification and intervention of TCM constitution takes a longer effect and could help to maintain the stable period of AR and to reduce the use of medicines due to the recurrent symptoms.
作者
李昕蓉
曹文灿
蒋明君
冯胜岚
敬然
李林霜
刘洋
张勤修
LI Xin-rong;CAO Wen-can;JIANG Ming-jun;FENG Sheng-lan;JING Ran;LI Lin-shuang;LIU Yang;ZHANG Qin-xiu(Affiliated Hospital of Chengdu University of TCM,Chengdu 610072,China;Chengdu University of TCM,Chengdu 610072,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第8期5079-5083,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81774131)
2019年度中央引导地方发展专项(No.2019ZYD054)
成都中医药大学“杏林学者”学科人才科研提升计划(青年学者)(No.QNXZ2019016)
2019年度成都中医药大学附属医院科技发展基金(No.2019KP03)
四川省高校人文社会科学重点研究基地项目(No.2021XT87)。
关键词
变应性鼻炎
中医体质学
体质辨识
体质干预
实效性随机对照试验
视觉模型拟评分
药物积分
Allergic rhinitis
Traditional Chinese medicine constitution
Constitution identification
Constitution intervention
Pragmatic randomized controlled trial
Visual analogue scale(VAS)
Drug integration