摘要
趋化因子受体4(CXCR4)在许多肿瘤细胞表面高表达,它可以作为肿瘤干细胞的标志物,其表达与肿瘤的恶性程度及病人的预后直接相关。靶向CXCR4 PET/CT显像在疾病的诊断、CXCR4靶向治疗病例选择、疗效评价等方面具有很大的应用潜力。就靶向CXCR4 PET/CT分子探针及其在肿瘤诊疗中的应用研究进展进行综述,总结分析各种探针的特点及临床转化情况,为CXCR4临床应用转化提供帮助。
Chemokine receptor 4(CXCR4),highly expressed on the surfaces of various tumor cells,can be used as a marker of tumor stem cells.The expression of CXCR4 correlates with the tumor malignancy and the prognosis of patients.CXCR4 as a target for PET/CT imaging shows great potentials in the disease diagnosis,case selection for CXCR4-target treatment and the evaluation of therapeutic effect.We reviewed the research progresses of targeted CXCR4 PET/CT molecular probe and its application in tumor diagnosis and treatment,summarized the characteristics and clinical transformation of various probes,so as to provide help for the clinical application and transformation of CXCR4.
作者
孙芳芳
杜雪梅(审校)
SUN Fangfang;DU Xuemei(Department of Nuclear Medicine,First Affiliate Hospital of Dalian Medical University,Dalian 116022,China)
出处
《国际医学放射学杂志》
北大核心
2021年第5期584-588,共5页
International Journal of Medical Radiology