Janus激酶抑制药的研究现状

Research status of Janus kinase inhibitors

Janus激酶-信号转导和转录激活因子(JAK-STAT)信号通路与炎症和自身免疫性疾病的发病机制有关,该通路中蛋白的失活、突变以及过度表达会导致严重的疾病,包括自身免疫性疾病、肿瘤和血液疾病。本文综述了JAKs抑制药的临床应用和安全性等问题,旨在为医药工作者开发新型药物提供参考。

Janus kinase-signal transducer and activator of transcription(JAK-STAT)signaling pathway plays critical roles in orchestrating of the immune system and relates to the pathogenesis of inflammation and autoimmune diseases.The inactivation,mutation and overexpression of proteins in this pathway can lead to serious diseases,including autoimmune disorders,neoplasms and hematological disorders.This article reviews the clinical applications and safety of JAK inhibitors with the aim of informing pharmaceutical practitioners in the development of novel drugs.