基于EWAS的高原汉族与藏族人群饮酒行为影响因素研究

Study on the drinking behavior of highland Han and Zang nationality populations and influence factors based on EWAS

[目的]基于“国家重点研发计划——西南区域自然人群队列”,分析高原汉族与藏族人群的饮酒行为特征及其相关影响因素。[方法]研究基于西南区域自然人群队列项目,针对高原的汉族与拉萨藏族队列人群共计18277人,分析调查对象的人口学特征与饮酒行为特征。使用全环境关联研究(Environment-Wide Association Study,EWAS)方法分析2个民族的饮酒行为相关影响因素。[结果]高原汉族与拉萨藏族饮酒率分别为30%和31.9%;对于每周饮酒者,每天或几乎每天都饮者所占比例高原汉族(77.4%)高于拉萨藏族(58.6%)。高原汉族饮酒品种以≥40°的高度白酒为主(84.5%),拉萨藏族以啤酒(94.5%)与青稞酒(6.6%)为主。高原汉族中,性别、职业类型、是否吸烟与饮酒行为的发生相关,而在拉萨藏族中,饮酒行为与年龄、性别、婚姻状态、职业类型、教育水平、是否吸烟有关。[结论]高原汉族与拉萨藏族人群在饮酒状况、每周饮酒频率、饮酒品种以及每日酒精摄入量的差异有统计学意义。性别、年龄、婚姻状况、吸烟状况、教育程度是藏族人群饮酒行为的主要影响因素。

Objective To analyze the drinking behavior characteristics and related influencing factors of plateau Han and Xizang nationality populations based on the“Southwest Regional Natural Population Cohort”of the National Key Research and Development Program.Methods The study was based on the Southwest Regional Natural Population Cohort Project,and analyzed the demographic characteristics and drinking behaviors of 18,277 highland Han and Zang nationality cohort populations in Lhasa.The factors associated with the drinking behavior of the two ethnic groups were analyzed by the Environment-Wide Association Study(EWAS)method.Results The drinking rates were 30%for the Plateau Han Chinese and 31.9%for Lhasa the Zang.For weekly drinkers,the proportion of daily or almost daily drinkers was higher among the Plateau Han(77.4%)than among Lhasa the Zang(58.6%).Mainly high white wine of Highland Han Chinese was≥40°(84.5%),while Lhasa the Zang drank mainly beer(94.5%)and barley wine(6.6%).Among the plateau Han Chinese,gender,type of occupation and whether smoking were associated with the occurrence of drinking behavior,while among the Lhasa the Zang,drinking behavior was associated with age,gender,marital status,occupation type,education level and whether smoking.Conclusions There was statistical significant differences between plateau Han Chinese and Lhasa the Zang populations in terms of drinking status,weekly frequency of drinking,variety of drinking,and daily alcohol intake.Gender,age,marital status,smoking status,and education level are the main influencing factors of drinking behavior among the Zang population.