口腔鳞癌Survivin表达及其在血管生成中的作用

Study of survivin expression and angiogenesis in oral squamous cell carcinoma

目的研究口腔鳞癌(oral squamous cell carcinoma,OSCC)中生存素(Survivin)的表达及其在血管生成中的作用。方法采用免疫组织化学方法,检测OSCC标本中Survivin、环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)及CD34的表达,并测定其微血管密度值(MVD)。SPSS22.0软件行统计学分析。结果106例OSCC组织中,Survivin与COX-2、VEGF表达明显相关(P<0.05)。Survivin阳性组MVD值高于阴性组(P<0.01)。结论Survivin促进了OSCC组织的血管生成,COX-2和VEGF参加了其作用。

Objective:To explore the relationships between Survivin expression and angiogenesis in oral squamous cell carcinoma.Methods:The Survivin,COX-2,VEGF and CD34 expressions were evalulated by immunohistochemical method.Results:The expressions of Survivin and COX-2,VEGF in oral squamous cell carcinoms were significantly positively correlated(P<0.05).There was significant difference of MVD between Survivin positive oral squamous cell carcinoma and negative ones(P<0.01).Conclusion:The present findings suggest that there is some link between Survivin and angiogenesis in oral squamous cell carcinom,partly attributing to the effect of COX-2 and VEGF.