蔬菜摄入与肝癌风险关系的Meta分析

A meta-analysis of the relationship between vegetable intake and the risk of liver cancer

目的探讨蔬菜摄入量与肝癌发生风险的关联性,为疾病的预防提供科学依据。方法系统检索2020年11月前国内外公开发表的有关蔬菜摄入量与肝癌风险的病例对照和队列研究,合并分析其最高摄入水平与最低水平之间肝癌发病风险的效应值及95%CI。采用Stata 11.0和Revman 5.3软件进行统计分析。结果研究共纳入12个病例对照研究和9个队列研究,共涉及1961683名受试者和5023名肝癌患者。食用蔬菜对肝癌的预防有显著的保护作用[RR=0.68,95%CI(0.56,0.82),P<0.01]。在亚组分析中各分层均显示摄入蔬菜可降低肝癌的风险。Begg′s检验(P=0.124)和漏斗图提示未见发表偏倚。结论研究结果表明,较高的蔬菜摄入量可以降低肝癌的发生风险。还需要更多更大样本量的前瞻性研究,以及良好的混杂因素控制来进一步评估。

Objective:To explore the relationship between vegetable intake and the risk of liver cancer,and to provide a scientific basis for disease prevention and treatment.Methods:Case-control and cohort studies on vegetable intake and liver cancer risk published at home and abroad before November 2020 were systematically retrieved,and the effect value and 95%CI of liver cancer risk between the highest and lowest intake levels were combined to make analysis.Stata 11.0 and Revman 5.3 software were used for statistical analysis.Results:This study included 12 case-control studies and 9 cohort studies,involving a total of 1961683 subjects and 5023 liver cancer patients.Eating vegetables had a significant protective effect on liver cancer[RR=0.68,95%CI(0.56,0.82),P<0.01].All strata in the subgroup analysis showed that the intake of vegetables could reduce the risk of liver cancer.The Begg′s test(P=0.124)and the funnel plot indicated no publication bias.Conclusion:The research results show that higher vegetable intake can reduce the risk of liver cancer.More prospective studies with larger sample sizes and good control of confounding factors are needed for further evaluation.