系统性红斑狼疮的胃肠道损伤

Gastrointestinal injury in systemic lupus erythematosus

系统性红斑狼疮(systemic lupus erythematosus,SLE)的胃肠道损伤是风湿免疫科医师在临床工作中常见的一类疑难复杂的疾病表型。SLE胃肠道受累的临床表现多样,鉴别诊断困难,疾病严重度易被低估。可表现为肠系膜血管炎、假性肠梗阻、蛋白丢失性胃肠病、肝炎、胰腺炎、急性无石性胆囊炎、非肝硬化性门脉高压与结节性再生性增生等。早期识别胃肠道损伤的临床表型,积极行糖皮质激素联合免疫抑制剂治疗,以及充分的胃肠道支持治疗有助于缓解SLE病情活动,并改善预后。

Gastrointestinal injury in systemic lupus erythematosus(SLE)is a common and complicated disease entity for rheumatologist.SLE gastrointestinal involvement has multiple clinical manifestations,the differential diagnosis is difficult and the disease sevevity is likely to be underestimated.Gastrointestinal injury involvements in SLE include lupus mesenteric vasculitis,intestinal pseudo-obstruction,protein-losing gastroenteropathy,hepatitis,pancreatitis,acute acalculous cholecystitis,non-cirrhotic portal hypertension and nodular regenerative hyperplasia.The early recognition,active application of corticosteroids combined with immunosuppressants,as well as supportive measure are crucial for the relief of SLE and better prognosis in SLE patients with gastrointestinal involvement.