归芍地黄汤联合康柏西普治疗肝肾亏虚型湿性年龄相关性黄斑变性的疗效研究

Curative Effect of Guishao Dihuang Decoction Combined with Conbercept in Treatment of Wet Age-Related Macular Degeneration of Liver and Kidney Deficiency

目的:观察归芍地黄汤加减联合康柏西普治疗肝肾亏虚型wAMD患者的疗效及对血清TLR3表达的影响及机理。方法:将符合纳入标准的肝肾亏虚型wAMD患者随机分为归芍地黄汤加减联合康柏西普(治疗组)与单用康柏西普(对照组)各30例,41只眼。比较2组患者的BCVA、CMT、眼底出血、渗出及CNV渗漏等疗效差异及血清TLR3水平变化。结果:经治疗,2组病例BCVA均好转,CMT变薄,TLR3含量减低,眼底情况如出血、渗出均见吸收,均以治疗组患者的临床疗效提高较对照组更突出,差异有统计学意义。结论:治疗组对肝肾亏虚型wAMD的疗效更具优势;可更好地改善肝肾亏虚的wAMD患者临床表现及降低血清TLR3水平,推测归芍地黄汤加减或通过降低血清TLR3水平起到治疗wAMD的作用。

Objective:To observe the curative effect of Guishao Dihuang Decoction combined with Conbercept in the treatment of patients with liver and kidney deficiency wAMD and its effect on serum TLR3 expression and its mechanism.Methods:Patients with liver and kidney deficiency type wAMD who met the inclusion criteria were randomly divided into 30 cases each with Guishao Dihuang Decoction plus or minus combined with Conbercept (treatment group) and Conbercept alone (control group),41 eyes.The differences in curative effect of BCVA,CMT,fundus hemorrhage,exudation and CNV leakage and changes in serum TLR3 levels were compared between the two groups.Results:After treatment,the BCVA of the two groups improved,the CMT became thinner,the TLR3 content was reduced,and the fundus conditions such as bleeding and exudation were absorbed.The improvement in clinical efficacy of the treatment group was more prominent than that of the control group,and the difference was statistically significant.significance.Conclusion:The treatment group has more advantages in the curative effect of liver and kidney deficiency type wAMD;it can better improve the clinical manifestations of liver and kidney deficiency wAMD patients and reduce serum TLR3 levels.It is speculated that Guishao Dihuang Decoction may be modified or reduced by reducing serum TLR3 levels.Play a role in the treatment of wAMD.