胸腔镜微创术与传统开胸术治疗非小细胞肺癌的对比分析

Comparative Analysis of Thoracoscopic Microtrauma and Conventional Thoracotomy in the Treatment of Non-small Cell Lung Cancer

目的比较分析胸腔镜微创手术与开胸手术治疗非小细胞肺癌患者的临床疗效。方法将我院收治的126例非小细胞肺癌患者随机等分为两组,胸腔镜组(n=63)采用胸腔镜微创手术治疗,传统组(n=63)采用传统开胸手术治疗,比较两组患者围术期指标、治疗前后肺功能情况和并发症发生情况。结果胸腔镜组和传统组手术时间、引流时间、清理的淋巴结个数差异无统计学意义(P>0.05),但胸腔镜组术中出血量和胸腔引流量更少,住院天数更短(P<0.05)。治疗前两组患者肺活量(vital capacity,VC)、用力呼气容积(forced expiratory volume in one second,FEV1)和每分钟最大通气量(maximal voluntary ventilation,MVV)差异无统计学意义(P>0.05),治疗3天、3个月后胸腔镜组VC、FEV1和MVV均优于传统组(P<0.05)。胸腔镜组并发症发生率(14.29%)低于传统组(30.15%)(P<0.05)。结论胸腔镜微创手术治疗非小细胞肺癌较开胸手术的临床综合疗效更优。

Objective To compare the clinical effect of thoracoscopic minimally invasive surgery and thoracotomy in the treatment of non-small cell lung cancer.Methods 126 patients with NSCLC were randomly divided into two groups.The thoracoscopic group(n=63)was treated with thoracoscopy minimally invasive surgery,and the traditional group(n=63)was treated by traditional thoracotomy.The perioperative indexes,lung function and complications were compared between the two groups.Results There was no significant difference in operation time,drainage time and the number of lymph nodes between thoracoscopic group and traditional group(P>0.05),however,the amount of intraoperative bleeding and thoracic drainage in the thoracoscopic group were less,and the length of hospital stay was shorter(P<0.05).Before treatment,there was no significant difference in vital capacity(VC),forced expiratory volume in one second(FEV1)and maximum voluntary ventilation(MVV)between the two groups(P>0.05),after 3 days and 3 months of treatment,VC,FEV1 and MVV in thoracoscopic group were better than those in traditional group(P<0.05).The incidence of complications in thoracoscopic group(14.29%)was lower than that in traditional group(30.15%)(P<0.05).Conclusion The minimally invasive thoracoscopy is more effective than that of thoracotomy in the treatment of NSCLC.