序贯放化疗与同步放化疗对肺癌患者放射性肺炎发生的影响及其与肺功能关系分析

Analysis on Influence of Sequential Chemoradiation and Concurrent Chemoradiation on the Occurrence of Radiation Pneumonia in Patients with Lung Cancer and Its Relationship with Lung Function

目的:探讨序贯放化疗与同步放化疗治疗肺癌的临床疗效、放射性肺炎(RP)发生率,以及对肺功能的影响。方法:选取2017年10月至2020年10月我院收治的肺癌患者60例。依据随机数字表按照简单随机分为序贯组与同步组,每组30例。序贯组采用序贯放化疗方案治疗,同步组采用同步放化疗方案治疗。比较两组临床疗效、放射性肺炎发生情况以及肺功能指标水平变化。结果:同步组总有效率(70.00%vs 46.67%)高于序贯组,但差异无统计学意义(P>0.05);同步组整体临床疗效要明显优于序贯组,差异具有统计学意义(P<0.05)。两组放射性肺炎发生率比较差异无统计学意义(P>0.05);秩和检验结果显示,序贯组放射性肺炎整体情况较于同步组更为严重,差异具有统计学意义(P<0.05)。两组治疗前各肺功能指标比较,差异均无统计学意义(均P>0.05);治疗后,同步组FEV1[(1.69±0.18 vs 1.42±0.31)L]、FVC[(3.02±0.27 vs 2.86±0.32)L]、FEV1/FVC[(56.09±4.86 vs 49.51±8.56)%]均明显高于序贯组,差异均具有统计学意义(均P<0.05)。结论:相较于序贯放化疗治疗方案,同步放化疗治疗肺癌整体疗效更优,能够减轻放射性肺炎程度,且可明显改善患者肺功能水平。

Objective:To investigate the clinical efficacy of sequential chemotherapy and concurrent chemotherapy for lung cancer,the incidence of radiation pneumonitis(RP),and the influence on lung function.Methods:A total of 60 lung cancer patients admitted to our hospital from October 2017 to October 2020 were selected.According to the random number table,they were simply randomly divided into sequential groups and synchronous groups,with 30 cases in each group.The sequential group was treated with sequential radiotherapy and chemotherapy,and the synchronous group was treated with concurrent radiochemotherapy.The clinical efficacy,incidence of radiation pneumonia and changes in lung function index levels were compared between the two groups.Results:The total effective rate of the synchronous group(70.00%vs 46.67%)was higher than that of the sequential group,but the difference was not statistically significant(P>0.05).The overall clinical efficacy of the synchronous group was significantly better than that of the sequential group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of radiation pneumonia between the two groups(P>0.05).The rank sum test showed that the overall situation of radiation pneumonia in the sequential group was more serious than that in the synchronous group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in lung function indexes between the two groups before treatment(all P>0.05);after treatment,FEV1[(1.69±0.18 vs 1.42±0.31)L],FVC[(3.02±0.27 vs 2.86)in the synchronous group±0.32)L],FEV1/FVC[(56.09±4.86 vs 49.51±8.56)%]were significantly higher than the sequential group,and the difference was statistically significant(all P<0.05).Conclusion:Compared with sequential radiotherapy and chemotherapy,the overall curative effect of concurrent radiotherapy for lung cancer is better.It can reduce the degree of radiation pneumonitis and can significantly improve the level of lung function in patients.