湿性愈合疗法在面部炎症性疾病中的临床疗效观察

Clinical observation of moist wound healing therapy in facial inflammatory diseases

目的评价湿性愈合疗法在面部炎症性疾病中的治疗效果和安全性。方法2021年1月-3月,于我科门诊收集确诊面部炎症性疾病患者109例,其中女性74例,男性35例。所有患者采用分级诊断、联合治疗的方法:100例轻、中度面部炎症性疾病患者,按照各自相应疾病的口服治疗方案连续使用2周;联合湿性愈合疗法为重组人表皮生长因子外用溶液和冷敷保湿修复敷料,每天至少3-5次,连续2周。9例重度面部炎症性疾病患者口服及湿性愈合疗法联合方案延长至4周。治疗1周、2周和4周判定疗效,随访观察期总计4周。结果联合湿性愈合疗法面部炎症性疾病治疗观察中,第一周显效44例(40.4%),第二周显效及痊愈75例(68.8%),第四周显效及痊愈109例(100.0%)。轻中度面部过敏性皮炎患者第四周全部痊愈,比例远高于轻中度粉刺痤疮(31.4%)及粉刺痤疮合并面部过敏性皮炎(10.0%),差异具有统计学意义(P<0.05)。观察中未见明显不良反应。结论湿性愈合疗法有助于缓解面部炎症性疾病的症状、体征,增加患者治疗舒适度,改善患者皮肤屏障功能,降低病情复发,可作为面部炎症性疾病的安全、有效的辅助治疗手段。

Objective To evaluate the therapeutic effect and safety of moist wound healing therapy in facial inflammatory diseases.Methods From January to March 2021,109 patients with confirmed facial inflammatory diseases were collected from our clinic,including 74 females and 35 males.All patients Adopting graded diagnosis and combined treatment methods:patients with mild and moderate facial inflammatory diseases should be used for 2 consecutive weeks according to their respective oral treatment plans;combined wet healing therapy is a topical solution of recombinant human epidermal growth factorand cold moisturizing and repairing dressings,at least 3-5 times a day for 2 weeks.The combined regimen of oral and wet healing therapy in 9 patients with severe facial inflammatory diseases was extended to 4 weeks.The curative effect was determined after treatment for 1 week,2 weeks and 4 weeks,and the follow-up observation period was 4 weeks in total.Results In the observation of combined wet healing therapy in the treatment of facial inflammatory diseases,44 cases(40.4%)were markedly effective in the first week,75 cases(68.8%)were markedly effective and cured in the second week,and 109 cases(100.0%)were markedly effective and cured in the fourth week.Patients with mild to moderate facial allergic dermatitis all recovered in the fourth week,and the proportion was much higher than mild to moderate acne(31.4%)and acne acne combined with facial allergic dermatitis(10.0%),the difference was statistically significant(P<0.05).During the observation,except for 2 patients who experienced acupuncture-like sensation immediately after use,it disappeared within half an hour,and there were no obvious adverse reactions in the rest.Conclusion Moist wound healing therapy can help relieve the symptoms and signs of facial inflammatory diseases,increase patient comfort,improve the skin barrier function of patients,and reduce recurrence.It can be used as a safe and effective auxiliary treatment for facial inflammatory diseases.