摘要
脉冲场消融(pulsed field ablation,PFA)作为一种非热消融技术,是治疗房颤的新型消融方式。这种能量形式采用一系列持续数微秒的高振幅电脉冲,当强脉冲电场使细胞膜通透性增加时,就会发生不可逆电穿孔,从而导致细胞稳态遭到破坏甚至死亡。由于脉冲电场具有独特的非热性和组织特异性,因此与射频和冷冻消融相比,PFA的应用范围更广、安全性更高,且发挥作用更快。本文主要介绍了PFA的原理和特性,阐明了PFA用于房颤治疗的组织特异性和应用局限性。
Pulsed field ablation(PFA)as a non-thermal ablation technology is a novel method for ablating atrial fibrillation.This form of energy employs a series of high-amplitude electric pulses lasting for several microseconds;when a strong pulsed electric field increases the membrane permeability,irreversible electroporation will occur,leading to the disruption of cellular homeostasis and even cell death.Since pulsed electric field has distinct non-thermal property and tissue specificity,PFA can be applied in a wider range with higher safety and shorter time to work compared with radiofrequency or cryoballoon ablation.This paper mainly introduces the principles and characteristics of PFA,and illustrates its tissue specificity and limitations in the treatment of atrial fibrillation.
作者
路桥
张先林
王洪巨
LU Qiao;ZHANG Xianlin;WANG Hongju(Department of Cardiology,the First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233000,China)
出处
《实用心电学杂志》
2021年第5期322-327,共6页
Journal of Practical Electrocardiology
基金
安徽省高校自然科学研究重点项目(KJ2019A0401)。
关键词
房颤
脉冲场消融
不可逆电穿孔
导管射频消融
冷冻球囊消融
atrial fibrillation
pulsed field ablation
irreversible electroporation
catheter radiofrequency ablation
cryoballoon ablation
