住院精神分裂症患者抗精神病药联合使用的效果分析

Analysis on the efficacy of combined use of antipsychotics in inpatients with schizophrenia

目的探讨住院精神分裂症患者抗精神病药联合使用效果。方法回顾性分析茂名市第三人民医院2019年1月至2020年1月住院精神分裂症患者80例,以患者不同用药方案分为两组,每组各40例。单一用药组以奥氮平片进行药物治疗,联合用药组以奥氮平片、丙戊酸钠片、劳拉西泮进行药物治疗。比较两组治疗前后阳性与阴性症状量表(PANSS)评分、生活质量综合评定问卷(GQOLI)评分、副反应量表(TESS)评分、患者用药总依从性、治疗至出院时间、再入院率。结果两组治疗前PANSS评分、GQOLI评分比较,差异无统计学意义(P>0.05);治疗后,两组PANSS评分、GQOLI评分优于治疗前,且联合用药组PANSS评分、GQOLI评分优于单一用药组,差异有统计学意义(P<0.05);联合用药组TESS评分与单一用药组比较,差异无统计学意义(P>0.05);联合用药组用药总依从性高于单一用药组,出院时间短于单一用药组,再入院率低于单一用药组,差异均有统计学意义(P<0.05)。结论住院精神分裂症患者在抗精神病药物使用中,联合用药临床疗效高于单一用药,能够有效改善患者精神病症状,提高患者生命质量,缩短患者治疗时间,提高用药依从性,降低再入院率。且联合用药治疗下,药物副反应与单一用药无差异,用药安全性较高,值得推广。

Objective To explore the efficacy of combined use of antipsychotics in inpatients with schizophrenia.Methods A total of 80 inpatients with schizophrenia admitted to the Third People's Hospital of Maoming City from January 2019 to January 2020 were retrospectively analyzed.These patients were divided into two groups with different medication regimens,with 40 rases in each group.The single medication group was treated with olanzapine tablets,while the combined medication group was treated with olanzapine tablets,sodium valproate tablets,and lorazepam.The scores of Positive and Negative Symptom Scale(PANSS),scores of Generic Quality of Life Inventory(GQOLI),and scores of Treatment Emergent Symptom Scale(TESS),the total of medication compliance of patients,treatmentto-discharge time,and readmission rate before and after treatment were compared between the two groups.Results There were no statistically significant differences between the two groups in the PANSS scores and GQOLI scores before treatment(P>0.05).After treatment,the PANSS scores and GQOLI scores of the two groups were better than those before treatment,and the PANSS scores and GQOLI scores of the combined medication group were better than those of the single medication group,with statistically significant differences(P<0.05).There was no statistically significant difference between the combined medication group and the single medication group in the TESS scores(P>0.05).The total of medication compliance of the combined medication group was higher than that of the single medication group,the treatment-to-discharge time of the combined medication group was shorter than that of the single medication group,and the readmission rate of the combined medication group was lower than that of the single medication group,all with statistically significant differences(P<0.05).Conclusion For inpatients with schizophrenia,the clinical efficacy of combined medication of antipsychotics is higher than that of single medication,which can effectively improve the psychiatric symptoms,enhance the quality of life,shorten the treatment time,improve medication compliance,and reduce the readmission rate of patients.In addition,there is no difference between combined medication and single medication in the side effects,and the safety of combined medi cation is higher,which is worthy of promotion.