Ⅰ型血小板结合蛋白基序解聚蛋白样金属蛋白酶7基因rs3825807位点单核苷酸多态性与冠心病易感性关系的Meta分析

The association between SNP(rs3825807) in a disintegrin and metalloproteinase with thrombospondin-like motifs gene and coronary artery disease:A Meta-analysis

目的:通过系统评价与Meta分析探索Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶7(ADAMTS7)基因rs3825807位点单核苷酸的多态性与冠心病发病风险的关联。方法:计算机检索PubMed, Web of Science, Cochrane Library,中国知网,万方,维普和中国生物医学数据库,以获取ADAMTS7基因rs3825807多态性与冠心病易感性的原始研究。检索时限均为建库至2019年12月6日。由两位研究者独立筛选文献、提取数据并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果:共纳入6个病例-对照研究,观察组包括4 989例病例,对照组包含5 471例。Meta分析结果显示,患者ADAMTS7基因rs3825807多态性与冠心病的发病风险增加有相关性(AA vs, GG:OR=21.07,95%CI:1.61~275.95,P=0.02;AG vs. GG:OR=6.80,95%CI:0.77~60.11,P=0.08;AA+AG vs. GG:OR=13.19,95%CI:1.09~158.97,P=0.04;AA vs. AG+GG:OR=2.39,95%CI:1.44~3.96,P=0.0007;A vs. G:OR=23.44,95%CI:8.19~67.10,P<0.00001)。结论:患者ADAMTS7基因rs3825807多态性是冠心病的发病风险因素之一。受纳入研究数量和质量限制,本研究需更多的高质量临床研究予以验证。

Objective: To evaluate the association between the SNP(rs3825807)in ADAMTS7 gene and the susceptibility of coronary artery disease. Methods: Databases including PubMed, Web of Science, CNKI, WanFang Data, VIP and CBM were searched from inception to December 6, 2019 to collect case-control studies about SNP(rs3825807)in ADAMTS7 gene and the susceptibility of coronary artery disease.Two reviewers independently screened the studies, extracted data and assessed the risk of bias of included studies, and then, meta-analysis was performed using RevMan 5.3 software. Results: A total of six studies were included, which involved 4989 patients and 5471 controls.The result of meta-analysis showed that there was significant association between ADAMTS7 gene rs3825807 polymorphism and increased risk of CHD.(AA vs. GG:OR=21.07,95%CI:1.61-275.95,P=0.02;AG vs. GG:OR=6.80,95%CI:0.77-60.11,P=0.08;AA+AG vs. GG:OR=13.19,95%CI:1.09-158.97,P=0.04;AA vs. AG+GG:OR=2.39,95%CI:1.44-3.96,P=0.0007;A vs. G:OR=23.44,95%CI:8.19-67.10,P<0.00001). Conclusions: The current evidence shows that ADAMTS7 gene rs3825807 polymorphism may be a genetic risk factor for CHD. Due to the limited quantity and quality of the included studies, more high quality studies are needed to verify the above conclusion.