帕罗西汀联合认知行为疗法治疗强迫症的效果

The effect of paroxetine combined with cognitive behavioral therapy in the treatment of obsessive-compulsive disorder

目的探讨强迫症(Obsessive-compulsive disorder,OCD)患者采用帕罗西汀联合认知行为疗法治疗的效果。方法选取2018年1月至2020年6月本院收治的110例OCD患者为研究对象,采用随机抽签的方式将患者分组进行研究,将抽取单号及双号的患者分别列入对照组与观察组,每组各55例,两组在服用帕罗西汀的基础上,观察组接受认知行为疗法,对照组无特殊处理,对比两组患者的治疗效果,采用耶鲁-布朗强迫症量表(Y-BOCS)对两组患者的症状改善情况进行评分,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)对患者的焦虑及抑郁情绪进行评分,采用汤旦林(TDL)生活质量量表对两组患者的生活质量改善情况进行评分。结果观察组的治疗有效率为96.36%,对照组为81.82%,组间比较,差异有统计学意义(P<0.05);治疗后两组Y-BOCS评分下降显著,观察组下降幅度更显著(P<0.05);治疗后两组SAS及SDS评分下降显著,观察组评分下降幅度更显著(P<0.05);治疗后两组TDL评分提升显著,观察组评分提升幅度高于对照组(P<0.05)。结论针对OCD患者,帕罗西汀联合认知行为疗法治疗疗效更佳,能更好地帮助患者缓解症状,改善患者的焦虑及抑郁情绪,改善其生活质量,值得临床借鉴。

Objective To investigate the effect of paroxetine combined with cognitive behavioral therapy in patients with obsessive-compulsive disorder(OCD).Methods A total of 110 OCD patients admitted to this hospital from January 2018 to June 2020 were selected as the research subjects.The patients were divided into groups by random lottery method.Patients with single and double numbers were included in the control group and the observation group,with 55 cases in each group.On the basis of taking paroxetine,the observation group received cognitive behavioral therapy.The treatment effect of the two groups was compared.The Yale-Brown Obsessive-Compulsive Disorder Scale was used to score the improvement in symptoms of the two groups of patients.Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)were used to score patients′anxiety and depression.The Tangdanlin(TDL)Quality of Life Scale was used to score the improvement of the quality of life of the two groups of patients.Results The effective treatment rate was 96.36%in the observation group and 81.82%in the observation group.There was a significant difference between the groups(P<0.05).After treatment,the Y-BOCS score of the two groups decreased significantly,and the comparative analysis between the groups showed that the decrease in the observation group was more significant(P<0.05).The SAS and SDS scores of the two groups decreased significantly after treatment,and the comparative analysis between the groups showed that the score of the observation group decreased more significantly(P<0.05).The TDL scores of the two groups increased significantly after treatment,and the comparative analysis between the groups showed that the scores of the observation group increased significantly than the control group(P<0.05).Conclusion For OCD patients,paroxetine combined with cognitive behavioral therapy has a better therapeutic effect,which can better help patients relieve symptoms,improve their anxiety and depression,and improve their quality of life.It is worthy of clinical reference.