双环化反应在构建碳环骨架中的应用研究

Study on the application of bicyclic reaction in the construction of carbon ring skeleton

双环化反应具有成环连续性、串联会聚性、成键有效性的特点,可分为分子内双环化和分子间双环化两种不同的形式。该反应可用于构建吡啶、呋喃、噻吩等杂环化合物,在碳环骨架构建中也得到了充分研究。对该合成策略进行充分论述,将为后续工作的开展提供指导。

Bicyclic reaction has the characteristics of cyclization continuity,series convergence and bonding effectiveness,which can be divided into two different forms:intramolecular bicyclic and intermolecular bicyclic.The reaction can be used to construct heterocyclic compounds such as pyridine,furan and thiophene,and it has also been fully studied in the construction of carbon ring skeleton.A full discussion of the synthesis strategy will provide guidance for the follow-up work.